Abstract
Readily-available 1,1,1,2-tetrafluoroethane (Klea HFC-134a) can be converted, via a two-pot sequence into a range of Z--fluoroalkenoyl derivatives following addition reactions to aldehydes. Reaction adducts can be processed into enals and enones upon hydride reduction or Grignard reagent addition in high yield.
Original language | English |
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Pages (from-to) | 2453–2455 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 41 |
Issue number | 14 |
DOIs | |
Publication status | Published - 1 Apr 2000 |
Keywords
- Z-α-fluoroalkenoyl
- 1,1,1,2-tetrafluoroethane
- hydride reduction
- reagents