Short, stereoselective syntheses of α-fluoroalkenoate derivatives, α-fluoroenones and α-fluoroenals from HFC-134a

M Kanai, Jonathan Percy

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Readily-available 1,1,1,2-tetrafluoroethane (Klea HFC-134a) can be converted, via a two-pot sequence into a range of Z--fluoroalkenoyl derivatives following addition reactions to aldehydes. Reaction adducts can be processed into enals and enones upon hydride reduction or Grignard reagent addition in high yield.
Original languageEnglish
Pages (from-to)2453–2455
Number of pages3
JournalTetrahedron Letters
Volume41
Issue number14
DOIs
Publication statusPublished - 1 Apr 2000

Keywords

  • Z-α-fluoroalkenoyl
  • 1,1,1,2-tetrafluoroethane
  • hydride reduction
  • reagents

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