Shining a light on clinical spectroscopy: translation of diagnostic IR, 2D-IR and Raman spectroscopy towards the clinic

Holly J. Butler, James M. Cameron, Cerys A. Jenkins, Gordon Hithell, Samantha Hume, Neil T. Hunt, Matthew J. Baker

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Abstract

In recent years, the application of vibrational spectroscopy in biomedical research has rapidly expanded; covering aspects of pharmaceutical development, to point-of-care technologies. Vibrational spectroscopy techniques such as Fourier-transform IR (FTIR), and Raman spectroscopy have been at the forefront of this movement, with their complementary information able to shine light onto a range of medical applications. As a relative newcomer to biomedical applications, two-dimensional (2D)-IR is also gaining traction in the field. Here we describe the recent development of these techniques as analytical tools in medical science, and their relative advancements towards the clinic.
Original languageEnglish
Article number100003
Number of pages11
JournalClinical Spectroscopy
Volume1
DOIs
Publication statusPublished - 19 Feb 2020

Keywords

  • clinical translation
  • vibrational spectroscopy
  • infrared
  • raman
  • 2DIR
  • biofluids
  • tissue

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