Shining a light on clinical spectroscopy: translation of diagnostic IR, 2D-IR and Raman spectroscopy towards the clinic

Holly J. Butler; James M. Cameron; Cerys A.  Jenkins; Gordon Hithell; Samantha Hume; Neil T. Hunt; Matthew J. Baker

doi:10.1016/j.clispe.2020.100003

Shining a light on clinical spectroscopy: translation of diagnostic IR, 2D-IR and Raman spectroscopy towards the clinic

Holly J. Butler, James M. Cameron, Cerys A. Jenkins, Gordon Hithell, Samantha Hume, Neil T. Hunt, Matthew J. Baker

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Abstract

In recent years, the application of vibrational spectroscopy in biomedical research has rapidly expanded; covering aspects of pharmaceutical development, to point-of-care technologies. Vibrational spectroscopy techniques such as Fourier-transform IR (FTIR), and Raman spectroscopy have been at the forefront of this movement, with their complementary information able to shine light onto a range of medical applications. As a relative newcomer to biomedical applications, two-dimensional (2D)-IR is also gaining traction in the field. Here we describe the recent development of these techniques as analytical tools in medical science, and their relative advancements towards the clinic.

Original language	English
Article number	100003
Number of pages	11
Journal	Clinical Spectroscopy
Volume	1
DOIs	https://doi.org/10.1016/j.clispe.2020.100003
Publication status	Published - 19 Feb 2020

Keywords

clinical translation
vibrational spectroscopy
infrared
raman
2DIR
biofluids
tissue

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10.1016/j.clispe.2020.100003Licence: CC BY 4.0

Butler-etal-CS-2020-Shining-a-light-on-clinical-spectroscopyFinal published version, 1.09 MBLicence: CC BY 4.0

EPSRC Doctoral Training Grant - DTA, University of Strathclyde
McFarlane, A. (Principal Investigator)
EPSRC (Engineering and Physical Sciences Research Council)
1/10/13 → 30/09/17
Project: Research - Studentship

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title = "Shining a light on clinical spectroscopy: translation of diagnostic IR, 2D-IR and Raman spectroscopy towards the clinic",

abstract = "In recent years, the application of vibrational spectroscopy in biomedical research has rapidly expanded; covering aspects of pharmaceutical development, to point-of-care technologies. Vibrational spectroscopy techniques such as Fourier-transform IR (FTIR), and Raman spectroscopy have been at the forefront of this movement, with their complementary information able to shine light onto a range of medical applications. As a relative newcomer to biomedical applications, two-dimensional (2D)-IR is also gaining traction in the field. Here we describe the recent development of these techniques as analytical tools in medical science, and their relative advancements towards the clinic.",

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doi = "10.1016/j.clispe.2020.100003",

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AU - Butler, Holly J.

AU - Cameron, James M.

AU - Jenkins, Cerys A.

AU - Hithell, Gordon

AU - Hume, Samantha

AU - Hunt, Neil T.

AU - Baker, Matthew J.

PY - 2020/2/19

Y1 - 2020/2/19

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AB - In recent years, the application of vibrational spectroscopy in biomedical research has rapidly expanded; covering aspects of pharmaceutical development, to point-of-care technologies. Vibrational spectroscopy techniques such as Fourier-transform IR (FTIR), and Raman spectroscopy have been at the forefront of this movement, with their complementary information able to shine light onto a range of medical applications. As a relative newcomer to biomedical applications, two-dimensional (2D)-IR is also gaining traction in the field. Here we describe the recent development of these techniques as analytical tools in medical science, and their relative advancements towards the clinic.

KW - clinical translation

KW - vibrational spectroscopy

KW - infrared

KW - raman

KW - 2DIR

KW - biofluids

KW - tissue

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DO - 10.1016/j.clispe.2020.100003

M3 - Article

SN - 2666-0547

VL - 1

JO - Clinical Spectroscopy

JF - Clinical Spectroscopy

M1 - 100003

ER -

Shining a light on clinical spectroscopy: translation of diagnostic IR, 2D-IR and Raman spectroscopy towards the clinic

Abstract

Keywords

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EPSRC Doctoral Training Grant - DTA, University of Strathclyde

Cite this