Shaped hemocompatible aerogels from cellulose phosphates: preparation and properties

Falk Liebner; Ramona Dunareanu; Martina Opietnik; Emmerich Haimer; Martin Wendland; Carsten Werner; Manfred Maitz; Philipp Seib; Marie-Alexandra Neouze; Antje Potthast; Thomas Rosenau

doi:10.1515/hf.2011.163

Shaped hemocompatible aerogels from cellulose phosphates: preparation and properties

Falk Liebner, Ramona Dunareanu, Martina Opietnik, Emmerich Haimer, Martin Wendland, Carsten Werner, Manfred Maitz, Philipp Seib, Marie-Alexandra Neouze, Antje Potthast, Thomas Rosenau

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Hemocompatible, shaped cellulose phosphate aerogels were obtained from phosphorylated cellulosic pulps of low degree of phosphorylation (DS_P≤0.20) by dissolution in stabilized NMMO×H₂O, shaping, reprecipitation with ethanol and subsequent scCO₂ drying. The novel aerogels were found to be promising materials for cell scaffolding and bone grafting. Special features include their interconnected and spread porosity, highly porous surface and microstructure, good hemocompatibility, and suitable hydroxyl apatite-binding environment. Adsorption of Ca²⁺ ions to the phosphate groups did not invert the negative inflammatory response observed after phosphorylating cellulose, but increased platelet-dependent parameters of hemostasis.

Original language	English
Pages (from-to)	317-321
Number of pages	5
Journal	Holzforschung
Volume	66
Issue number	3
Early online date	17 Nov 2011
DOIs	https://doi.org/10.1515/hf.2011.163
Publication status	Published - 31 Mar 2012

Keywords

aerogels
cell scaffolding materials
cellulose phosphates
hemocompatibility
Lyocell

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10.1515/hf.2011.163

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abstract = "Hemocompatible, shaped cellulose phosphate aerogels were obtained from phosphorylated cellulosic pulps of low degree of phosphorylation (DSP≤0.20) by dissolution in stabilized NMMO×H2O, shaping, reprecipitation with ethanol and subsequent scCO2 drying. The novel aerogels were found to be promising materials for cell scaffolding and bone grafting. Special features include their interconnected and spread porosity, highly porous surface and microstructure, good hemocompatibility, and suitable hydroxyl apatite-binding environment. Adsorption of Ca2+ ions to the phosphate groups did not invert the negative inflammatory response observed after phosphorylating cellulose, but increased platelet-dependent parameters of hemostasis.",

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T1 - Shaped hemocompatible aerogels from cellulose phosphates

T2 - preparation and properties

AU - Liebner, Falk

AU - Dunareanu, Ramona

AU - Opietnik, Martina

AU - Haimer, Emmerich

AU - Wendland, Martin

AU - Werner, Carsten

AU - Maitz, Manfred

AU - Seib, Philipp

AU - Neouze, Marie-Alexandra

AU - Potthast, Antje

AU - Rosenau, Thomas

PY - 2012/3/31

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N2 - Hemocompatible, shaped cellulose phosphate aerogels were obtained from phosphorylated cellulosic pulps of low degree of phosphorylation (DSP≤0.20) by dissolution in stabilized NMMO×H2O, shaping, reprecipitation with ethanol and subsequent scCO2 drying. The novel aerogels were found to be promising materials for cell scaffolding and bone grafting. Special features include their interconnected and spread porosity, highly porous surface and microstructure, good hemocompatibility, and suitable hydroxyl apatite-binding environment. Adsorption of Ca2+ ions to the phosphate groups did not invert the negative inflammatory response observed after phosphorylating cellulose, but increased platelet-dependent parameters of hemostasis.

AB - Hemocompatible, shaped cellulose phosphate aerogels were obtained from phosphorylated cellulosic pulps of low degree of phosphorylation (DSP≤0.20) by dissolution in stabilized NMMO×H2O, shaping, reprecipitation with ethanol and subsequent scCO2 drying. The novel aerogels were found to be promising materials for cell scaffolding and bone grafting. Special features include their interconnected and spread porosity, highly porous surface and microstructure, good hemocompatibility, and suitable hydroxyl apatite-binding environment. Adsorption of Ca2+ ions to the phosphate groups did not invert the negative inflammatory response observed after phosphorylating cellulose, but increased platelet-dependent parameters of hemostasis.

KW - aerogels

KW - cell scaffolding materials

KW - cellulose phosphates

KW - hemocompatibility

KW - Lyocell

U2 - 10.1515/hf.2011.163

DO - 10.1515/hf.2011.163

M3 - Article

SN - 0018-3830

VL - 66

SP - 317

EP - 321

JO - Holzforschung

JF - Holzforschung

IS - 3

ER -

Shaped hemocompatible aerogels from cellulose phosphates: preparation and properties

Abstract

Keywords

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