Shaped hemocompatible aerogels from cellulose phosphates: preparation and properties

Falk Liebner, Ramona Dunareanu, Martina Opietnik, Emmerich Haimer, Martin Wendland, Carsten Werner, Manfred Maitz, Philipp Seib, Marie-Alexandra Neouze, Antje Potthast, Thomas Rosenau

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Hemocompatible, shaped cellulose phosphate aerogels were obtained from phosphorylated cellulosic pulps of low degree of phosphorylation (DSP≤0.20) by dissolution in stabilized NMMO×H2O, shaping, reprecipitation with ethanol and subsequent scCO2 drying. The novel aerogels were found to be promising materials for cell scaffolding and bone grafting. Special features include their interconnected and spread porosity, highly porous surface and microstructure, good hemocompatibility, and suitable hydroxyl apatite-binding environment. Adsorption of Ca2+ ions to the phosphate groups did not invert the negative inflammatory response observed after phosphorylating cellulose, but increased platelet-dependent parameters of hemostasis.
Original languageEnglish
Pages (from-to)317-321
Number of pages5
JournalHolzforschung
Volume66
Issue number3
Early online date17 Nov 2011
DOIs
Publication statusPublished - 31 Mar 2012

    Fingerprint

Keywords

  • aerogels
  • cell scaffolding materials
  • cellulose phosphates
  • hemocompatibility
  • Lyocell

Cite this

Liebner, F., Dunareanu, R., Opietnik, M., Haimer, E., Wendland, M., Werner, C., ... Rosenau, T. (2012). Shaped hemocompatible aerogels from cellulose phosphates: preparation and properties. Holzforschung, 66(3), 317-321. https://doi.org/10.1515/hf.2011.163