Sex hormones and modulation of immunity against leishmaniasis

Heidi Snider, Claudio Lezama-Davila, J. Alexander, Abhay R. Satoskar

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Sex-associated hormones such as estradiol, testosterone and progesterone have all been shown to modulate immune responses, which can result in differential disease outcomes between males and females, as well as between pregnant and nonpregnant females. Most parasitic diseases, including leishmaniasis, usually result in more severe disease in males compared with females. This review highlights our current knowledge concerning the role of sex hormones in modulating leishmaniasis in both clinical settings and experimental disease models.
Original languageEnglish
Pages (from-to)106-113
Number of pages7
JournalNeuroimmunomodulation
Volume16
Issue number2
DOIs
Publication statusPublished - 2009

Keywords

  • leishmaniasis
  • sex-associated hormones
  • immune responses
  • biomedical sciences
  • pharmacology

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