Abstract
Pulmonary arterial hypertension (PAH) occurs in women more than men whereas survival in men is worse than in women. In recent years, much research has been carried out to understand these sex differences in PAH. This article discusses clinical and preclinical studies that have investigated the influences of sex, serotonin, obesity, estrogen, estrogen synthesis, and estrogen metabolism on bone morphogenetic protein receptor type II signaling, the pulmonary circulation and right ventricle in both heritable and idiopathic pulmonary hypertension.
| Original language | English |
|---|---|
| Pages (from-to) | 217-228 |
| Number of pages | 12 |
| Journal | Clinics in Chest Medicine |
| Volume | 42 |
| Issue number | 1 |
| Early online date | 13 Jan 2021 |
| DOIs | |
| Publication status | Published - 31 Mar 2021 |
Keywords
- BMPR2
- estrogens
- obesity
- pulmonary circulation
- pulmonary hypertension
- right ventricle
- serotonin
- sex