Sex differences in pulmonary hypertension

Hannah Morris; Nina Denver; Rosemary Gaw; Hicham Labazi; Kirsty Mair; Margaret R. MacLean

doi:10.1016/j.ccm.2020.10.005

Sex differences in pulmonary hypertension

Hannah Morris, Nina Denver, Rosemary Gaw, Hicham Labazi, Kirsty Mair, Margaret R. MacLean

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

11 Citations (Scopus)

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Abstract

Pulmonary arterial hypertension (PAH) occurs in women more than men whereas survival in men is worse than in women. In recent years, much research has been carried out to understand these sex differences in PAH. This article discusses clinical and preclinical studies that have investigated the influences of sex, serotonin, obesity, estrogen, estrogen synthesis, and estrogen metabolism on bone morphogenetic protein receptor type II signaling, the pulmonary circulation and right ventricle in both heritable and idiopathic pulmonary hypertension.

Original language	English
Pages (from-to)	217-228
Number of pages	12
Journal	Clinics in Chest Medicine
Volume	42
Issue number	1
Early online date	13 Jan 2021
DOIs	https://doi.org/10.1016/j.ccm.2020.10.005
Publication status	Published - 31 Mar 2021

Keywords

BMPR2
estrogens
obesity
pulmonary circulation
pulmonary hypertension
right ventricle
serotonin
sex

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10.1016/j.ccm.2020.10.005

Morris-etal-CCM2021-Sex-differences-pulmunory-hypertensionAccepted author manuscript, 382 KBLicence: CC BY-NC-ND 4.0

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AU - Denver, Nina

AU - Gaw, Rosemary

AU - Labazi, Hicham

AU - Mair, Kirsty

AU - MacLean, Margaret R.

PY - 2021/3/31

Y1 - 2021/3/31

N2 - Pulmonary arterial hypertension (PAH) occurs in women more than men whereas survival in men is worse than in women. In recent years, much research has been carried out to understand these sex differences in PAH. This article discusses clinical and preclinical studies that have investigated the influences of sex, serotonin, obesity, estrogen, estrogen synthesis, and estrogen metabolism on bone morphogenetic protein receptor type II signaling, the pulmonary circulation and right ventricle in both heritable and idiopathic pulmonary hypertension.

AB - Pulmonary arterial hypertension (PAH) occurs in women more than men whereas survival in men is worse than in women. In recent years, much research has been carried out to understand these sex differences in PAH. This article discusses clinical and preclinical studies that have investigated the influences of sex, serotonin, obesity, estrogen, estrogen synthesis, and estrogen metabolism on bone morphogenetic protein receptor type II signaling, the pulmonary circulation and right ventricle in both heritable and idiopathic pulmonary hypertension.

KW - BMPR2

KW - estrogens

KW - obesity

KW - pulmonary circulation

KW - pulmonary hypertension

KW - right ventricle

KW - serotonin

KW - sex

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ER -

Sex differences in pulmonary hypertension

Abstract

Keywords

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