Sex differences in pulmonary hypertension

Hannah Morris, Nina Denver, Rosemary Gaw, Hicham Labazi, Kirsty Mair, Margaret R. MacLean

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)
20 Downloads (Pure)


Pulmonary arterial hypertension (PAH) occurs in women more than men whereas survival in men is worse than in women. In recent years, much research has been carried out to understand these sex differences in PAH. This article discusses clinical and preclinical studies that have investigated the influences of sex, serotonin, obesity, estrogen, estrogen synthesis, and estrogen metabolism on bone morphogenetic protein receptor type II signaling, the pulmonary circulation and right ventricle in both heritable and idiopathic pulmonary hypertension.

Original languageEnglish
Pages (from-to)217-228
Number of pages12
JournalClinics in Chest Medicine
Issue number1
Early online date13 Jan 2021
Publication statusPublished - 31 Mar 2021


  • BMPR2
  • estrogens
  • obesity
  • pulmonary circulation
  • pulmonary hypertension
  • right ventricle
  • serotonin
  • sex


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