Abstract
Single-molecule detection by surface-enhanced resonance Raman scattering (SERRS) spectroscopy has been demonstrated for a variety of molecules. The detection of single molecules that do not have a resonance contribution, SERS, has been shown in the case of adenine. However, when colloidal particles isolated on planar substrates are used as the enhancing medium, the presence of anomalous signals significantly complicates the analysis of the spectra. Selection of a silver colloid that minimizes these spurious signals should improve the ultra-sensitive detection of non-resonant single molecules by SERS. A range of silver colloids, prepared by different methods, were investigated with respect to their activity and stability. Minimal anomalous signals were obtained from hydroxylamine-reduced silver colloids, which suggests that this colloid will be better for ultra-sensitive SE(R)RS experiments compared to the more common citrate- and borohydride-reduced silver colloids.
| Language | English |
|---|---|
| Pages | 202-206 |
| Number of pages | 5 |
| Journal | Journal of Raman Spectroscopy |
| Volume | 43 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2012 |
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Keywords
- SERS
- silver colloid
- anomalous signals
- nanoparticles
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SERS activity and stability of the most frequently used silver colloids. / Larmour, I. A.; Faulds, K.; Graham, D.
In: Journal of Raman Spectroscopy, Vol. 43, No. 2, 02.2012, p. 202-206.Research output: Contribution to journal › Article
TY - JOUR
T1 - SERS activity and stability of the most frequently used silver colloids
AU - Larmour, I. A.
AU - Faulds, K.
AU - Graham, D.
PY - 2012/2
Y1 - 2012/2
N2 - Single-molecule detection by surface-enhanced resonance Raman scattering (SERRS) spectroscopy has been demonstrated for a variety of molecules. The detection of single molecules that do not have a resonance contribution, SERS, has been shown in the case of adenine. However, when colloidal particles isolated on planar substrates are used as the enhancing medium, the presence of anomalous signals significantly complicates the analysis of the spectra. Selection of a silver colloid that minimizes these spurious signals should improve the ultra-sensitive detection of non-resonant single molecules by SERS. A range of silver colloids, prepared by different methods, were investigated with respect to their activity and stability. Minimal anomalous signals were obtained from hydroxylamine-reduced silver colloids, which suggests that this colloid will be better for ultra-sensitive SE(R)RS experiments compared to the more common citrate- and borohydride-reduced silver colloids.
AB - Single-molecule detection by surface-enhanced resonance Raman scattering (SERRS) spectroscopy has been demonstrated for a variety of molecules. The detection of single molecules that do not have a resonance contribution, SERS, has been shown in the case of adenine. However, when colloidal particles isolated on planar substrates are used as the enhancing medium, the presence of anomalous signals significantly complicates the analysis of the spectra. Selection of a silver colloid that minimizes these spurious signals should improve the ultra-sensitive detection of non-resonant single molecules by SERS. A range of silver colloids, prepared by different methods, were investigated with respect to their activity and stability. Minimal anomalous signals were obtained from hydroxylamine-reduced silver colloids, which suggests that this colloid will be better for ultra-sensitive SE(R)RS experiments compared to the more common citrate- and borohydride-reduced silver colloids.
KW - SERS
KW - silver colloid
KW - anomalous signals
KW - nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=84857787663&partnerID=8YFLogxK
U2 - 10.1002/jrs.3038
DO - 10.1002/jrs.3038
M3 - Article
VL - 43
SP - 202
EP - 206
JO - Journal of Raman Spectroscopy
T2 - Journal of Raman Spectroscopy
JF - Journal of Raman Spectroscopy
SN - 0377-0486
IS - 2
ER -