SERRS-active nanoparticle-polymer beads for ultra-sensitive biodiagnostic applications

Robert J. Stokes, A. Hernandez-Santana, A. Macaskill, P.A.G. Cormack, W.E. Smith, D. Graham

Research output: Contribution to journalArticle

Abstract

A new approach to the synthesis of polymer beads that give surface-enhanced resonance Raman scattering (SERRS) is reported. Controlling the aggregation of silver nanoparticles by silica seeding prior to encapsulation into a polymer is shown to yield a highly reproducible bead with a relative standard deviation (RSD) diameter down to 5%. The reliable and intense SERRS response is attributed to the combined resonance of the reporter dye (435 nm) and the nanoparticle cluster (440 nm). The presence of heavier clustered particles within the bead core means the activity can be further improved to around 93% by means of sedimentation purification. This is a significant step towards a reproducible and reliable reporter unit for the many varied potential biodiagnostic applications of SERRS.
LanguageEnglish
Pages57-61
Number of pages5
JournalMicro and Nano Letters
Volume1
Issue number1
DOIs
Publication statusPublished - Jul 2006

Fingerprint

resonance scattering
beads
Raman scattering
Polymers
Raman spectra
Nanoparticles
nanoparticles
polymers
inoculation
purification
standard deviation
dyes
silver
Encapsulation
Silver
Sedimentation
Silicon Dioxide
silicon dioxide
Purification
Coloring Agents

Keywords

  • polymer bead
  • surface-enhanced resonance Raman scattering
  • SERRS
  • silver nanoparticles
  • silica seeding
  • bio-analytical tagging

Cite this

@article{9586b7fed85a475786627bf2d0e7eec5,
title = "SERRS-active nanoparticle-polymer beads for ultra-sensitive biodiagnostic applications",
abstract = "A new approach to the synthesis of polymer beads that give surface-enhanced resonance Raman scattering (SERRS) is reported. Controlling the aggregation of silver nanoparticles by silica seeding prior to encapsulation into a polymer is shown to yield a highly reproducible bead with a relative standard deviation (RSD) diameter down to 5{\%}. The reliable and intense SERRS response is attributed to the combined resonance of the reporter dye (435 nm) and the nanoparticle cluster (440 nm). The presence of heavier clustered particles within the bead core means the activity can be further improved to around 93{\%} by means of sedimentation purification. This is a significant step towards a reproducible and reliable reporter unit for the many varied potential biodiagnostic applications of SERRS.",
keywords = "polymer bead, surface-enhanced resonance Raman scattering, SERRS, silver nanoparticles, silica seeding, bio-analytical tagging",
author = "Stokes, {Robert J.} and A. Hernandez-Santana and A. Macaskill and P.A.G. Cormack and W.E. Smith and D. Graham",
year = "2006",
month = "7",
doi = "10.1049/mnl:20065032",
language = "English",
volume = "1",
pages = "57--61",
journal = "Micro and Nano Letters",
issn = "1750-0443",
number = "1",

}

SERRS-active nanoparticle-polymer beads for ultra-sensitive biodiagnostic applications. / Stokes, Robert J.; Hernandez-Santana, A.; Macaskill, A.; Cormack, P.A.G.; Smith, W.E.; Graham, D.

In: Micro and Nano Letters, Vol. 1, No. 1, 07.2006, p. 57-61.

Research output: Contribution to journalArticle

TY - JOUR

T1 - SERRS-active nanoparticle-polymer beads for ultra-sensitive biodiagnostic applications

AU - Stokes, Robert J.

AU - Hernandez-Santana, A.

AU - Macaskill, A.

AU - Cormack, P.A.G.

AU - Smith, W.E.

AU - Graham, D.

PY - 2006/7

Y1 - 2006/7

N2 - A new approach to the synthesis of polymer beads that give surface-enhanced resonance Raman scattering (SERRS) is reported. Controlling the aggregation of silver nanoparticles by silica seeding prior to encapsulation into a polymer is shown to yield a highly reproducible bead with a relative standard deviation (RSD) diameter down to 5%. The reliable and intense SERRS response is attributed to the combined resonance of the reporter dye (435 nm) and the nanoparticle cluster (440 nm). The presence of heavier clustered particles within the bead core means the activity can be further improved to around 93% by means of sedimentation purification. This is a significant step towards a reproducible and reliable reporter unit for the many varied potential biodiagnostic applications of SERRS.

AB - A new approach to the synthesis of polymer beads that give surface-enhanced resonance Raman scattering (SERRS) is reported. Controlling the aggregation of silver nanoparticles by silica seeding prior to encapsulation into a polymer is shown to yield a highly reproducible bead with a relative standard deviation (RSD) diameter down to 5%. The reliable and intense SERRS response is attributed to the combined resonance of the reporter dye (435 nm) and the nanoparticle cluster (440 nm). The presence of heavier clustered particles within the bead core means the activity can be further improved to around 93% by means of sedimentation purification. This is a significant step towards a reproducible and reliable reporter unit for the many varied potential biodiagnostic applications of SERRS.

KW - polymer bead

KW - surface-enhanced resonance Raman scattering

KW - SERRS

KW - silver nanoparticles

KW - silica seeding

KW - bio-analytical tagging

U2 - 10.1049/mnl:20065032

DO - 10.1049/mnl:20065032

M3 - Article

VL - 1

SP - 57

EP - 61

JO - Micro and Nano Letters

T2 - Micro and Nano Letters

JF - Micro and Nano Letters

SN - 1750-0443

IS - 1

ER -