Abstract
| Language | English |
|---|---|
| Pages | 57-61 |
| Number of pages | 5 |
| Journal | Micro and Nano Letters |
| Volume | 1 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 2006 |
Fingerprint
Keywords
- polymer bead
- surface-enhanced resonance Raman scattering
- SERRS
- silver nanoparticles
- silica seeding
- bio-analytical tagging
Cite this
}
SERRS-active nanoparticle-polymer beads for ultra-sensitive biodiagnostic applications. / Stokes, Robert J.; Hernandez-Santana, A.; Macaskill, A.; Cormack, P.A.G.; Smith, W.E.; Graham, D.
In: Micro and Nano Letters, Vol. 1, No. 1, 07.2006, p. 57-61.Research output: Contribution to journal › Article
TY - JOUR
T1 - SERRS-active nanoparticle-polymer beads for ultra-sensitive biodiagnostic applications
AU - Stokes, Robert J.
AU - Hernandez-Santana, A.
AU - Macaskill, A.
AU - Cormack, P.A.G.
AU - Smith, W.E.
AU - Graham, D.
PY - 2006/7
Y1 - 2006/7
N2 - A new approach to the synthesis of polymer beads that give surface-enhanced resonance Raman scattering (SERRS) is reported. Controlling the aggregation of silver nanoparticles by silica seeding prior to encapsulation into a polymer is shown to yield a highly reproducible bead with a relative standard deviation (RSD) diameter down to 5%. The reliable and intense SERRS response is attributed to the combined resonance of the reporter dye (435 nm) and the nanoparticle cluster (440 nm). The presence of heavier clustered particles within the bead core means the activity can be further improved to around 93% by means of sedimentation purification. This is a significant step towards a reproducible and reliable reporter unit for the many varied potential biodiagnostic applications of SERRS.
AB - A new approach to the synthesis of polymer beads that give surface-enhanced resonance Raman scattering (SERRS) is reported. Controlling the aggregation of silver nanoparticles by silica seeding prior to encapsulation into a polymer is shown to yield a highly reproducible bead with a relative standard deviation (RSD) diameter down to 5%. The reliable and intense SERRS response is attributed to the combined resonance of the reporter dye (435 nm) and the nanoparticle cluster (440 nm). The presence of heavier clustered particles within the bead core means the activity can be further improved to around 93% by means of sedimentation purification. This is a significant step towards a reproducible and reliable reporter unit for the many varied potential biodiagnostic applications of SERRS.
KW - polymer bead
KW - surface-enhanced resonance Raman scattering
KW - SERRS
KW - silver nanoparticles
KW - silica seeding
KW - bio-analytical tagging
U2 - 10.1049/mnl:20065032
DO - 10.1049/mnl:20065032
M3 - Article
VL - 1
SP - 57
EP - 61
JO - Micro and Nano Letters
T2 - Micro and Nano Letters
JF - Micro and Nano Letters
SN - 1750-0443
IS - 1
ER -