SERRS-active nanoparticle-polymer beads for ultra-sensitive biodiagnostic applications

Robert J. Stokes; A. Hernandez-Santana; A. Macaskill; P.A.G. Cormack; W.E. Smith; D. Graham

doi:10.1049/mnl:20065032

SERRS-active nanoparticle-polymer beads for ultra-sensitive biodiagnostic applications

Robert J. Stokes, A. Hernandez-Santana, A. Macaskill, P.A.G. Cormack, W.E. Smith, D. Graham

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

A new approach to the synthesis of polymer beads that give surface-enhanced resonance Raman scattering (SERRS) is reported. Controlling the aggregation of silver nanoparticles by silica seeding prior to encapsulation into a polymer is shown to yield a highly reproducible bead with a relative standard deviation (RSD) diameter down to 5%. The reliable and intense SERRS response is attributed to the combined resonance of the reporter dye (435 nm) and the nanoparticle cluster (440 nm). The presence of heavier clustered particles within the bead core means the activity can be further improved to around 93% by means of sedimentation purification. This is a significant step towards a reproducible and reliable reporter unit for the many varied potential biodiagnostic applications of SERRS.

Original language	English
Pages (from-to)	57-61
Number of pages	5
Journal	Micro and Nano Letters
Volume	1
Issue number	1
DOIs	https://doi.org/10.1049/mnl:20065032
Publication status	Published - Jul 2006

Keywords

polymer bead
surface-enhanced resonance Raman scattering
SERRS
silver nanoparticles
silica seeding
bio-analytical tagging

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10.1049/mnl:20065032

1 Finished

NMS: EPSRC Science and Innovation Nanometrology for Molecular Science, Medicine and Manufacture
Birch, D., Dawson, M., Faulds, K., Girkin, J., Graham, D., Martin, R., O'Donnell, K., Rolinski, O., Smith, W. & Wynne, K.
Scottish Funding Council SFC, EPSRC (Engineering and Physical Sciences Research Council)
1/08/08 → 31/01/12
Project: Research

Cite this

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title = "SERRS-active nanoparticle-polymer beads for ultra-sensitive biodiagnostic applications",

abstract = "A new approach to the synthesis of polymer beads that give surface-enhanced resonance Raman scattering (SERRS) is reported. Controlling the aggregation of silver nanoparticles by silica seeding prior to encapsulation into a polymer is shown to yield a highly reproducible bead with a relative standard deviation (RSD) diameter down to 5%. The reliable and intense SERRS response is attributed to the combined resonance of the reporter dye (435 nm) and the nanoparticle cluster (440 nm). The presence of heavier clustered particles within the bead core means the activity can be further improved to around 93% by means of sedimentation purification. This is a significant step towards a reproducible and reliable reporter unit for the many varied potential biodiagnostic applications of SERRS.",

keywords = "polymer bead, surface-enhanced resonance Raman scattering, SERRS, silver nanoparticles, silica seeding, bio-analytical tagging",

author = "Stokes, {Robert J.} and A. Hernandez-Santana and A. Macaskill and P.A.G. Cormack and W.E. Smith and D. Graham",

year = "2006",

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doi = "10.1049/mnl:20065032",

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T1 - SERRS-active nanoparticle-polymer beads for ultra-sensitive biodiagnostic applications

AU - Stokes, Robert J.

AU - Hernandez-Santana, A.

AU - Macaskill, A.

AU - Cormack, P.A.G.

AU - Smith, W.E.

AU - Graham, D.

PY - 2006/7

Y1 - 2006/7

N2 - A new approach to the synthesis of polymer beads that give surface-enhanced resonance Raman scattering (SERRS) is reported. Controlling the aggregation of silver nanoparticles by silica seeding prior to encapsulation into a polymer is shown to yield a highly reproducible bead with a relative standard deviation (RSD) diameter down to 5%. The reliable and intense SERRS response is attributed to the combined resonance of the reporter dye (435 nm) and the nanoparticle cluster (440 nm). The presence of heavier clustered particles within the bead core means the activity can be further improved to around 93% by means of sedimentation purification. This is a significant step towards a reproducible and reliable reporter unit for the many varied potential biodiagnostic applications of SERRS.

AB - A new approach to the synthesis of polymer beads that give surface-enhanced resonance Raman scattering (SERRS) is reported. Controlling the aggregation of silver nanoparticles by silica seeding prior to encapsulation into a polymer is shown to yield a highly reproducible bead with a relative standard deviation (RSD) diameter down to 5%. The reliable and intense SERRS response is attributed to the combined resonance of the reporter dye (435 nm) and the nanoparticle cluster (440 nm). The presence of heavier clustered particles within the bead core means the activity can be further improved to around 93% by means of sedimentation purification. This is a significant step towards a reproducible and reliable reporter unit for the many varied potential biodiagnostic applications of SERRS.

KW - polymer bead

KW - surface-enhanced resonance Raman scattering

KW - SERRS

KW - silver nanoparticles

KW - silica seeding

KW - bio-analytical tagging

U2 - 10.1049/mnl:20065032

DO - 10.1049/mnl:20065032

M3 - Article

VL - 1

SP - 57

EP - 61

JO - Micro and Nano Letters

JF - Micro and Nano Letters

SN - 1750-0443

IS - 1

ER -

SERRS-active nanoparticle-polymer beads for ultra-sensitive biodiagnostic applications

Abstract

Keywords

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NMS: EPSRC Science and Innovation Nanometrology for Molecular Science, Medicine and Manufacture

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