Sequence-specific dna detection using high-affinity lna-functionalized gold nanoparticles

Fiona McKenzie, K. Faulds, D. Graham

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The functionalization of gold nanoparticles with locked nucleic acid (LNA; see image) is reported. These nanoconjugate probes offer immense stability and selectivity towards complementary DNA, allowing the detection of specific DNA sequences.
LanguageEnglish
Pages1866-1868
Number of pages2
JournalSmall
Volume3
Issue number11
DOIs
Publication statusPublished - Nov 2007

Fingerprint

Nanoconjugates
DNA sequences
Nucleic acids
Gold
Nanoparticles
DNA
Complementary DNA
locked nucleic acid

Keywords

  • DNA
  • gold
  • hybridization
  • nanoparticles

Cite this

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title = "Sequence-specific dna detection using high-affinity lna-functionalized gold nanoparticles",
abstract = "The functionalization of gold nanoparticles with locked nucleic acid (LNA; see image) is reported. These nanoconjugate probes offer immense stability and selectivity towards complementary DNA, allowing the detection of specific DNA sequences.",
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Sequence-specific dna detection using high-affinity lna-functionalized gold nanoparticles. / McKenzie, Fiona; Faulds, K.; Graham, D.

In: Small, Vol. 3, No. 11, 11.2007, p. 1866-1868.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sequence-specific dna detection using high-affinity lna-functionalized gold nanoparticles

AU - McKenzie, Fiona

AU - Faulds, K.

AU - Graham, D.

PY - 2007/11

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AB - The functionalization of gold nanoparticles with locked nucleic acid (LNA; see image) is reported. These nanoconjugate probes offer immense stability and selectivity towards complementary DNA, allowing the detection of specific DNA sequences.

KW - DNA

KW - gold

KW - hybridization

KW - nanoparticles

UR - http://dx.doi.org/10.1002/smll.200700225

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DO - 10.1002/smll.200700225

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