Sequence-specific dna detection using high-affinity lna-functionalized gold nanoparticles

Fiona McKenzie, K. Faulds, D. Graham

Research output: Contribution to journal › Article

41 Citations (Scopus)

Abstract

The functionalization of gold nanoparticles with locked nucleic acid (LNA; see image) is reported. These nanoconjugate probes offer immense stability and selectivity towards complementary DNA, allowing the detection of specific DNA sequences.
Original languageEnglish
Pages (from-to)1866-1868
Number of pages2
JournalSmall
Volume3
Issue number11
DOIs
Publication statusPublished - Nov 2007

Keywords

  • DNA
  • gold
  • hybridization
  • nanoparticles

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    • Projects

    NMS: EPSRC Science and Innovation Nanometrology for Molecular Science, Medicine and Manufacture

    Birch, D., Dawson, M., Faulds, K., Girkin, J., Graham, D., Martin, R., O'Donnell, K., Rolinski, O., Smith, W. & Wynne, K.

    Scottish Funding Council SFC, EPSRC (Engineering and Physical Sciences Research Council)

    1/08/08 → 31/01/12

    Project: Research

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