Abstract
Sequence similarity alignment is a basic information processing method in bioinformatics. It is very important for discovering the information of function, structure and evolution in biological sequences. The main idea is to use a specific mathematical model or algorithm to find the maximum matching base or residual number between two or more sequences. The results of alignment reflect to what extent the algorithm reflects the similarity relationship between sequences and their biological characteristics. Therefore, the simple and effective algorithm of sequence similarity alignment in bioinformatics has always been a concern of biologists. This paper reviews some widely used sequence alignment algorithms including double-sequence alignment and multi-sequence alignment, simultaneously, introduces a method to call genetic variants from next-generation gene sequence data.
Original language | English |
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Title of host publication | Advances in Brain Inspired Cognitive Systems |
Subtitle of host publication | 10th International Conference, BICS 2019, Guangzhou, China, July 13–14, 2019, Proceedings |
Editors | Jinchang Ren, Amir Hussain, Huimin Zhao, Kaizhu Huang, Jiangbin Zheng, Jun Cai, Rongjun Chen, Yinyin Xiao |
Place of Publication | Cham, Switzerland |
Publisher | Springer |
Pages | 550-560 |
Number of pages | 11 |
ISBN (Electronic) | 9783030394318 |
ISBN (Print) | 9783030394301 |
DOIs | |
Publication status | Published - 1 Feb 2020 |
Event | 10th International Conference on Brain Inspired Cognitive Systems, BICS 2019 - Guangzhou, China Duration: 13 Jul 2019 → 14 Jul 2019 |
Conference
Conference | 10th International Conference on Brain Inspired Cognitive Systems, BICS 2019 |
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Country/Territory | China |
City | Guangzhou |
Period | 13/07/19 → 14/07/19 |
Keywords
- bioinformatics
- longest common subsequence (LCS)
- deoxyribonucleic acid (DNA)
- sequence alignment