Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugates

Jesús Mosquera, Mateo I. Sánchez, Julián Valero, Javier De Mendoza, M. Eugenio Vázquez, José L. Mascareñas

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Conjugation of a short peptide fragment from a bZIP protein to an oligoguanidinium tail results in a DNA-binding miniprotein that selectively interacts with composite sequences containing the peptide-binding site next to an A/T-rich tract. In addition to stabilizing the complex with the target DNA, the oligoguanidinium unit also endows the conjugate with cell internalization properties.

Original languageEnglish
Pages (from-to)4811-4814
Number of pages4
JournalChemical Communications
Volume51
Issue number23
DOIs
Publication statusPublished - 21 Mar 2015

Keywords

  • oligoguanidinium–peptide conjugates
  • DNA binding

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