Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugates

Jesús Mosquera; Mateo I. Sánchez; Julián Valero; Javier De Mendoza; M. Eugenio Vázquez; José L. Mascareñas

doi:10.1039/c4cc09525a

Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugates

Jesús Mosquera, Mateo I. Sánchez, Julián Valero, Javier De Mendoza, M. Eugenio Vázquez^*, José L. Mascareñas

^*Corresponding author for this work

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Conjugation of a short peptide fragment from a bZIP protein to an oligoguanidinium tail results in a DNA-binding miniprotein that selectively interacts with composite sequences containing the peptide-binding site next to an A/T-rich tract. In addition to stabilizing the complex with the target DNA, the oligoguanidinium unit also endows the conjugate with cell internalization properties.

Original language	English
Pages (from-to)	4811-4814
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	23
DOIs	https://doi.org/10.1039/c4cc09525a
Publication status	Published - 21 Mar 2015

Keywords

oligoguanidinium–peptide conjugates
DNA binding

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10.1039/c4cc09525a

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title = "Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugates",

abstract = "Conjugation of a short peptide fragment from a bZIP protein to an oligoguanidinium tail results in a DNA-binding miniprotein that selectively interacts with composite sequences containing the peptide-binding site next to an A/T-rich tract. In addition to stabilizing the complex with the target DNA, the oligoguanidinium unit also endows the conjugate with cell internalization properties.",

keywords = "oligoguanidinium–peptide conjugates, DNA binding",

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T1 - Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugates

AU - Mosquera, Jesús

AU - Sánchez, Mateo I.

AU - Valero, Julián

AU - De Mendoza, Javier

AU - Vázquez, M. Eugenio

AU - Mascareñas, José L.

PY - 2015/3/21

Y1 - 2015/3/21

N2 - Conjugation of a short peptide fragment from a bZIP protein to an oligoguanidinium tail results in a DNA-binding miniprotein that selectively interacts with composite sequences containing the peptide-binding site next to an A/T-rich tract. In addition to stabilizing the complex with the target DNA, the oligoguanidinium unit also endows the conjugate with cell internalization properties.

AB - Conjugation of a short peptide fragment from a bZIP protein to an oligoguanidinium tail results in a DNA-binding miniprotein that selectively interacts with composite sequences containing the peptide-binding site next to an A/T-rich tract. In addition to stabilizing the complex with the target DNA, the oligoguanidinium unit also endows the conjugate with cell internalization properties.

KW - oligoguanidinium–peptide conjugates

KW - DNA binding

UR - http://www.scopus.com/inward/record.url?scp=84924370797&partnerID=8YFLogxK

U2 - 10.1039/c4cc09525a

DO - 10.1039/c4cc09525a

M3 - Article

C2 - 25692277

AN - SCOPUS:84924370797

SN - 1359-7345

VL - 51

SP - 4811

EP - 4814

JO - Chemical Communications

JF - Chemical Communications

IS - 23

ER -

Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugates

Abstract

Keywords

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