Sensitivity analysis of programmed cell death and implications for crosstalk phenomena during tumor necrosis factor stimulation

T. Eissing, S. Waldherr, C. Gondro, Eric Bullinger, O. Sawodny, F. Allgöwer, P. Scheurich, T. Sauter

Research output: Contribution to conferencePaper

Abstract

Different methods for analyzing the sensitivity of the direct signal transduction pathway of receptor-induced apoptosis to parameter changes are presented. Apoptosis is a form of programmed cell death, removing unwanted cells within multicellular organisms to maintain a proper balance between cell reproduction and death. The results indicate the importance of controlling activated caspases by direct inhibition to prevent apoptosis. A misregulation of IAP molecules, one of the main inhibitors, appears to be especially critical. The results indicate how an increased production of this molecule promotes survival and might promote cancer progression, while a reduced degradation might not, thereby providing insight of potential pharmaceutical relevance and also stimulating experimental verification. The different engineering methods applied, nicely complement each other to provide valuable insight into this important process. Because IAPs, among others, are also an important connection to other signaling pathways, the results will enable a more efficient extension of the current model. This is outlined at the example of Tumor Necrosis Factor induced signaling pathways.
LanguageEnglish
Pages1746-1752
Number of pages7
DOIs
Publication statusPublished - 2006
EventIEEE International Conference on Control Applications - Munich, Germany
Duration: 4 Oct 20066 Oct 2006

Conference

ConferenceIEEE International Conference on Control Applications
Abbreviated titleCCA/CACSD/ISIC
CountryGermany
CityMunich
Period4/10/066/10/06

Fingerprint

Cell Death
Tumor Necrosis Factor-alpha
Apoptosis
Caspases
Reproduction
Signal Transduction
Pharmaceutical Preparations
Neoplasms

Keywords

  • tumor necrosis factor stimulation
  • programmed cell death
  • direct signal transduction

Cite this

Eissing, T., Waldherr, S., Gondro, C., Bullinger, E., Sawodny, O., Allgöwer, F., ... Sauter, T. (2006). Sensitivity analysis of programmed cell death and implications for crosstalk phenomena during tumor necrosis factor stimulation. 1746-1752. Paper presented at IEEE International Conference on Control Applications, Munich, Germany. https://doi.org/10.1109/CCA.2006.286137
Eissing, T. ; Waldherr, S. ; Gondro, C. ; Bullinger, Eric ; Sawodny, O. ; Allgöwer, F. ; Scheurich, P. ; Sauter, T. / Sensitivity analysis of programmed cell death and implications for crosstalk phenomena during tumor necrosis factor stimulation. Paper presented at IEEE International Conference on Control Applications, Munich, Germany.7 p.
@conference{5d7e35dfc45449afaed88ad5113b1524,
title = "Sensitivity analysis of programmed cell death and implications for crosstalk phenomena during tumor necrosis factor stimulation",
abstract = "Different methods for analyzing the sensitivity of the direct signal transduction pathway of receptor-induced apoptosis to parameter changes are presented. Apoptosis is a form of programmed cell death, removing unwanted cells within multicellular organisms to maintain a proper balance between cell reproduction and death. The results indicate the importance of controlling activated caspases by direct inhibition to prevent apoptosis. A misregulation of IAP molecules, one of the main inhibitors, appears to be especially critical. The results indicate how an increased production of this molecule promotes survival and might promote cancer progression, while a reduced degradation might not, thereby providing insight of potential pharmaceutical relevance and also stimulating experimental verification. The different engineering methods applied, nicely complement each other to provide valuable insight into this important process. Because IAPs, among others, are also an important connection to other signaling pathways, the results will enable a more efficient extension of the current model. This is outlined at the example of Tumor Necrosis Factor induced signaling pathways.",
keywords = "tumor necrosis factor stimulation, programmed cell death , direct signal transduction",
author = "T. Eissing and S. Waldherr and C. Gondro and Eric Bullinger and O. Sawodny and F. Allg{\"o}wer and P. Scheurich and T. Sauter",
year = "2006",
doi = "10.1109/CCA.2006.286137",
language = "English",
pages = "1746--1752",
note = "IEEE International Conference on Control Applications, CCA/CACSD/ISIC ; Conference date: 04-10-2006 Through 06-10-2006",

}

Eissing, T, Waldherr, S, Gondro, C, Bullinger, E, Sawodny, O, Allgöwer, F, Scheurich, P & Sauter, T 2006, 'Sensitivity analysis of programmed cell death and implications for crosstalk phenomena during tumor necrosis factor stimulation' Paper presented at IEEE International Conference on Control Applications, Munich, Germany, 4/10/06 - 6/10/06, pp. 1746-1752. https://doi.org/10.1109/CCA.2006.286137

Sensitivity analysis of programmed cell death and implications for crosstalk phenomena during tumor necrosis factor stimulation. / Eissing, T.; Waldherr, S.; Gondro, C.; Bullinger, Eric; Sawodny, O.; Allgöwer, F.; Scheurich, P.; Sauter, T.

2006. 1746-1752 Paper presented at IEEE International Conference on Control Applications, Munich, Germany.

Research output: Contribution to conferencePaper

TY - CONF

T1 - Sensitivity analysis of programmed cell death and implications for crosstalk phenomena during tumor necrosis factor stimulation

AU - Eissing, T.

AU - Waldherr, S.

AU - Gondro, C.

AU - Bullinger, Eric

AU - Sawodny, O.

AU - Allgöwer, F.

AU - Scheurich, P.

AU - Sauter, T.

PY - 2006

Y1 - 2006

N2 - Different methods for analyzing the sensitivity of the direct signal transduction pathway of receptor-induced apoptosis to parameter changes are presented. Apoptosis is a form of programmed cell death, removing unwanted cells within multicellular organisms to maintain a proper balance between cell reproduction and death. The results indicate the importance of controlling activated caspases by direct inhibition to prevent apoptosis. A misregulation of IAP molecules, one of the main inhibitors, appears to be especially critical. The results indicate how an increased production of this molecule promotes survival and might promote cancer progression, while a reduced degradation might not, thereby providing insight of potential pharmaceutical relevance and also stimulating experimental verification. The different engineering methods applied, nicely complement each other to provide valuable insight into this important process. Because IAPs, among others, are also an important connection to other signaling pathways, the results will enable a more efficient extension of the current model. This is outlined at the example of Tumor Necrosis Factor induced signaling pathways.

AB - Different methods for analyzing the sensitivity of the direct signal transduction pathway of receptor-induced apoptosis to parameter changes are presented. Apoptosis is a form of programmed cell death, removing unwanted cells within multicellular organisms to maintain a proper balance between cell reproduction and death. The results indicate the importance of controlling activated caspases by direct inhibition to prevent apoptosis. A misregulation of IAP molecules, one of the main inhibitors, appears to be especially critical. The results indicate how an increased production of this molecule promotes survival and might promote cancer progression, while a reduced degradation might not, thereby providing insight of potential pharmaceutical relevance and also stimulating experimental verification. The different engineering methods applied, nicely complement each other to provide valuable insight into this important process. Because IAPs, among others, are also an important connection to other signaling pathways, the results will enable a more efficient extension of the current model. This is outlined at the example of Tumor Necrosis Factor induced signaling pathways.

KW - tumor necrosis factor stimulation

KW - programmed cell death

KW - direct signal transduction

U2 - 10.1109/CCA.2006.286137

DO - 10.1109/CCA.2006.286137

M3 - Paper

SP - 1746

EP - 1752

ER -

Eissing T, Waldherr S, Gondro C, Bullinger E, Sawodny O, Allgöwer F et al. Sensitivity analysis of programmed cell death and implications for crosstalk phenomena during tumor necrosis factor stimulation. 2006. Paper presented at IEEE International Conference on Control Applications, Munich, Germany. https://doi.org/10.1109/CCA.2006.286137