Sensitivity analysis of programmed cell death and implications for crosstalk phenomena during tumor necrosis factor stimulation

T. Eissing, S. Waldherr, C. Gondro, Eric Bullinger, O. Sawodny, F. Allgöwer, P. Scheurich, T. Sauter

Research output: Contribution to conferencePaper


Different methods for analyzing the sensitivity of the direct signal transduction pathway of receptor-induced apoptosis to parameter changes are presented. Apoptosis is a form of programmed cell death, removing unwanted cells within multicellular organisms to maintain a proper balance between cell reproduction and death. The results indicate the importance of controlling activated caspases by direct inhibition to prevent apoptosis. A misregulation of IAP molecules, one of the main inhibitors, appears to be especially critical. The results indicate how an increased production of this molecule promotes survival and might promote cancer progression, while a reduced degradation might not, thereby providing insight of potential pharmaceutical relevance and also stimulating experimental verification. The different engineering methods applied, nicely complement each other to provide valuable insight into this important process. Because IAPs, among others, are also an important connection to other signaling pathways, the results will enable a more efficient extension of the current model. This is outlined at the example of Tumor Necrosis Factor induced signaling pathways.
Original languageEnglish
Number of pages7
Publication statusPublished - 2006
EventIEEE International Conference on Control Applications - Munich, Germany
Duration: 4 Oct 20066 Oct 2006


ConferenceIEEE International Conference on Control Applications
Abbreviated titleCCA/CACSD/ISIC


  • tumor necrosis factor stimulation
  • programmed cell death
  • direct signal transduction

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