Sensitivity analysis and parameter estimation of signal transduction pathways model

J.F. Jia, H. Yue

Research output: Contribution to conferencePaper

1 Citation (Scopus)

Abstract

Due to the high nonlinearity in system models, the large number of kinetics parameters involved, the inadequate measurement data in experiments and the noise pollution, etc., parameter estimation is therefore a challenging problem in systems biology. In this work, sensitivity analysis of model output with respect to model parameters is evaluated using Latin hypercube sampling method. Then, a new objective function is proposed based on the probability density function (PDF) of the system output, and particle swarm optimization is used to optimize the objective function through particles' cooperation and evolution. Taking NF-kappaB signal pathways model as an example, this method is applied to rank importance of parameters and to estimate the unknown sensitive parameters for complex signal transduction pathways model. The simulation results show the effectiveness of this new algorithm.

Original languageEnglish
Pages1357-1362
Number of pages6
Publication statusPublished - Aug 2009
Event7th Asian Control Conference, 2009 (ASCC 2009) - , Hong Kong
Duration: 27 Aug 200929 Aug 2009

Conference

Conference7th Asian Control Conference, 2009 (ASCC 2009)
CountryHong Kong
Period27/08/0929/08/09

    Fingerprint

Keywords

  • biological system modeling
  • kinetic theory
  • noise measurement
  • biology computing
  • parameter estimation
  • particle swarm optimisation
  • probability
  • sensitivity analysis

Cite this

Jia, J. F., & Yue, H. (2009). Sensitivity analysis and parameter estimation of signal transduction pathways model. 1357-1362. Paper presented at 7th Asian Control Conference, 2009 (ASCC 2009), Hong Kong.