Sensitivity analysis is normally used to analyze how sensitive a system is with respect to the change of parameters or initial conditions and is perhaps best known in systems biology via the formalism of metabolic control analysis [1, 2]. The nuclear factor B (NF-B) signalling pathway is an important cellular signalling pathway, of which protein phosphorylation is a major factor controlling the activation of further downstream events. The NF-κB proteins regulate numerous genes that play important roles in inter- and intra-cellular signalling, cellular stress responses, cell growth, survival, and apoptosis. As such, its specificity and its role in the temporal control of gene expression are of crucial physiological interest.
|Number of pages||2|
|Publication status||Published - 2007|
|Event||5th International Conference on Sensitivity Analysis of Model Output (SAMO2007) - Budapest, Hungary|
Duration: 18 Jun 2007 → …
|Conference||5th International Conference on Sensitivity Analysis of Model Output (SAMO2007)|
|Period||18/06/07 → …|
- sensitivity analysis
- signal transduction
Yue, H., Jia, J. F., Brown, M., Wang, H., & Kell, D. B. (2007). Sensitivity analysis and experimental design of a stiff signal transduction pathway model. Paper presented at 5th International Conference on Sensitivity Analysis of Model Output (SAMO2007), Budapest, Hungary.