Sensitivity analysis and experimental design of a stiff signal transduction pathway model

H. Yue, J.F. Jia, M. Brown, H. Wang, D.B. Kell

Research output: Contribution to conferencePaper

51 Downloads (Pure)

Abstract

Sensitivity analysis is normally used to analyze how sensitive a system is with respect to the change of parameters or initial conditions and is perhaps best known in systems biology via the formalism of metabolic control analysis [1, 2]. The nuclear factor B (NF-B) signalling pathway is an important cellular signalling pathway, of which protein phosphorylation is a major factor controlling the activation of further downstream events. The NF-κB proteins regulate numerous genes that play important roles in inter- and intra-cellular signalling, cellular stress responses, cell growth, survival, and apoptosis. As such, its specificity and its role in the temporal control of gene expression are of crucial physiological interest.
Original languageEnglish
Number of pages2
Publication statusPublished - 2007
Event5th International Conference on Sensitivity Analysis of Model Output (SAMO2007) - Budapest, Hungary
Duration: 18 Jun 2007 → …

Conference

Conference5th International Conference on Sensitivity Analysis of Model Output (SAMO2007)
CountryHungary
CityBudapest
Period18/06/07 → …

Keywords

  • sensitivity analysis
  • signal transduction

Fingerprint Dive into the research topics of 'Sensitivity analysis and experimental design of a stiff signal transduction pathway model'. Together they form a unique fingerprint.

  • Cite this

    Yue, H., Jia, J. F., Brown, M., Wang, H., & Kell, D. B. (2007). Sensitivity analysis and experimental design of a stiff signal transduction pathway model. Paper presented at 5th International Conference on Sensitivity Analysis of Model Output (SAMO2007), Budapest, Hungary.