Self-assembly of ultra-small micelles from amphiphilic lipopeptoids

King Hang Aaron Lau; Valeria  Castelletto; Thomas Kendall; Jan Sefcik; Ian W. Hamley; Mehedi Reza; Janne Ruokolainen

doi:10.1039/C6CC09888F

Self-assembly of ultra-small micelles from amphiphilic lipopeptoids

King Hang Aaron Lau, Valeria Castelletto, Thomas Kendall, Jan Sefcik, Ian W. Hamley, Mehedi Reza, Janne Ruokolainen

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

71 Downloads (Pure)

Abstract

Poly(N-substituted glycine) “peptoids” constitute a promising class of peptide-mimetic materials. We introduce the self-assembly of lipopeptoids into spherical micelles ca. 5 nm in diameter as well as larger assemblies by varying the peptoid sequence design. Our results point to design rules for the self-assembly of peptoid nanostructures, enabling the creation of stable, ultra-small pep- tidomimetic nanospheres.

Original language	English
Pages (from-to)	2178-2181
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	13
Early online date	25 Jan 2017
DOIs	https://doi.org/10.1039/C6CC09888F
Publication status	Published - 9 Feb 2017

Keywords

amphiphilic lipopeptoids
peptoids
peptoid nanostructures
peptidomimetic nanospheres

Access to Document

10.1039/C6CC09888FLicence: CC BY 3.0

Lau-etal-CC-2017-Self-assembly-of-ultra-small-micelles-from-amphiphilic-lipopeptoidsFinal published version, 2.12 MBLicence: CC BY 3.0

K. H. Aaron Lau, [he/him]
- aaron.laustrath.acuk
- Pure And Applied Chemistry - Senior Lecturer
Person: Academic

1 Finished

Dynamic peptoid biomaterial for stem cell delivery
Lau, K. H. A. (Principal Investigator)
Tenovus Scotland
15/01/16 → 14/04/17
Project: Research

Self-assembly of ultra-small micelles from amphiphilic lipopeptoids
Lau, K. H. A. (Creator), Kendall, T. (Creator), Sefcik, J. (Creator), Ruokolainen, J. (Creator), Reza, M. (Creator), Hamley, I. W. (Creator) & Castelletto, V. (Creator), University of Strathclyde, 30 Jan 2017
DOI: 10.15129/15d4068d-b268-45fd-bd6a-22b0cbae2ede
Dataset

34 Citations
1 Article

Peptoids for biomaterials science
Lau, K. H. A., Jan 2014, In: Biomaterials Science. 2, 5, p. 627-633 7 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
67 Citations (Scopus)

316 Downloads (Pure)

6 Participation in conference
6 Invited talk

Invited lecture at IMRE Singapore (Advanced Surfaces Lecture Series)
Lau, K. H. A. (Invited speaker)
14 Dec 2018
Activity: Talk or presentation types › Invited talk
Invited Talk at the Peptoid ITN Workshop
Lau, K. H. A. (Invited speaker)
1 Nov 2018
Activity: Talk or presentation types › Invited talk
4th London Polymer Group Symposium
Lau, K. H. A. (Invited speaker)
14 Nov 2018
Activity: Participating in or organising an event types › Participation in conference

Cite this

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title = "Self-assembly of ultra-small micelles from amphiphilic lipopeptoids",

abstract = "Poly(N-substituted glycine) “peptoids” constitute a promising class of peptide-mimetic materials. We introduce the self-assembly of lipopeptoids into spherical micelles ca. 5 nm in diameter as well as larger assemblies by varying the peptoid sequence design. Our results point to design rules for the self-assembly of peptoid nanostructures, enabling the creation of stable, ultra-small pep- tidomimetic nanospheres.",

keywords = "amphiphilic lipopeptoids, peptoids, peptoid nanostructures, peptidomimetic nanospheres",

author = "Lau, {King Hang Aaron} and Valeria Castelletto and Thomas Kendall and Jan Sefcik and Hamley, {Ian W.} and Mehedi Reza and Janne Ruokolainen",

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doi = "10.1039/C6CC09888F",

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AU - Lau, King Hang Aaron

AU - Castelletto, Valeria

AU - Kendall, Thomas

AU - Sefcik, Jan

AU - Hamley, Ian W.

AU - Reza, Mehedi

AU - Ruokolainen, Janne

PY - 2017/2/9

Y1 - 2017/2/9

N2 - Poly(N-substituted glycine) “peptoids” constitute a promising class of peptide-mimetic materials. We introduce the self-assembly of lipopeptoids into spherical micelles ca. 5 nm in diameter as well as larger assemblies by varying the peptoid sequence design. Our results point to design rules for the self-assembly of peptoid nanostructures, enabling the creation of stable, ultra-small pep- tidomimetic nanospheres.

AB - Poly(N-substituted glycine) “peptoids” constitute a promising class of peptide-mimetic materials. We introduce the self-assembly of lipopeptoids into spherical micelles ca. 5 nm in diameter as well as larger assemblies by varying the peptoid sequence design. Our results point to design rules for the self-assembly of peptoid nanostructures, enabling the creation of stable, ultra-small pep- tidomimetic nanospheres.

KW - amphiphilic lipopeptoids

KW - peptoids

KW - peptoid nanostructures

KW - peptidomimetic nanospheres

U2 - 10.1039/C6CC09888F

DO - 10.1039/C6CC09888F

M3 - Article

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VL - 53

SP - 2178

EP - 2181

JO - Chemical Communications

JF - Chemical Communications

IS - 13

ER -

Self-assembly of ultra-small micelles from amphiphilic lipopeptoids

Abstract

Keywords

Access to Document

Fingerprint

Profiles

K. H. Aaron Lau, [he/him]

Projects

Dynamic peptoid biomaterial for stem cell delivery

Datasets

Self-assembly of ultra-small micelles from amphiphilic lipopeptoids

Research output

Peptoids for biomaterials science

Activities

Invited lecture at IMRE Singapore (Advanced Surfaces Lecture Series)

Invited Talk at the Peptoid ITN Workshop

4th London Polymer Group Symposium

Cite this