Self-assembly of gold supraparticles with crystallographically aligned and strongly coupled nanoparticle building blocks for SERS and photothermal therapy

S. Paterson, S. A. Thompson, J. Gracie, A. W. Wark, R. de la Rica

Research output: Contribution to journalArticle

12 Citations (Scopus)
116 Downloads (Pure)

Abstract

A new method is introduced for self-assembling citrate-capped gold nanoparticles into supraparticles with crystallographically aligned building blocks. It consists in confining gold nanoparticles inside a cellulos acetate membrane. The constituent nanoparticles are in close contact in the superstructure, and therefore generate hot spots leading to intense SERS signals. They also generate more plasmonic heat than the nanoparticle building blocks. The supraparticles are internalized by cells and show low cytotoxicity, but can kill cancer cells when irradiated with a laser. This, along with the improved plasmonic properties arising from their assembly, makes the gold supraparticles promising materials for applications in bioimaging and nanomedicine.
Original languageEnglish
Pages (from-to)6232-6237
Number of pages7
JournalChemical Science
Volume7
Issue number9
Early online date20 Jun 2016
DOIs
Publication statusPublished - 1 Sep 2016

Keywords

  • self-assembly
  • gold nanoparticles
  • supraparticles
  • SERS
  • photothermal therapy

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