Self-assembly of cetyl linear polyethylenimine to give micelles, vesicles, and dense nanoparticles

A. Gray

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The involvement of macromolecules in the formation of biological and other membranes has important implications for structural biology and nanoengineering. Using cetyl polyethylenimines of varying molecular weight and hydrophobicity, it was found that polymer hydrophobicity (mol % cetylation) controlled the nature of the self-assembly, giving micellar (cetyl groups < 23 mol %), vesicular (cetyl groups = 23−42 mol % or cetyl groups = 3−42 mol % with cholesterol), and dense nanoparticle (cetyl groups ≥ 49 mol %) aggregates. Thick (up to 15 nm) membranes due to the polyelectrolyte coating with the amphiphile were observed with low levels of cetylation only, and both dn/dc (indirectly) and vesicle/nanoparticle size (directly) varied linearly with mol % cetylation (r = 0.96−0.99).
LanguageEnglish
Pages9114-9122
Number of pages9
JournalMacromolecules
Volume37
Issue number24
DOIs
Publication statusPublished - 2004

Fingerprint

Polyethyleneimine
Micelles
Hydrophobicity
Self assembly
Nanoparticles
Membranes
Amphiphiles
Cholesterol
Polyelectrolytes
Macromolecules
Polymers
Molecular weight
Coatings

Keywords

  • cetyl linear polyethylenimine
  • micelles
  • vesicles
  • nanoparticles

Cite this

@article{e142eb86dea44bec91f9830c4c9ab15e,
title = "Self-assembly of cetyl linear polyethylenimine to give micelles, vesicles, and dense nanoparticles",
abstract = "The involvement of macromolecules in the formation of biological and other membranes has important implications for structural biology and nanoengineering. Using cetyl polyethylenimines of varying molecular weight and hydrophobicity, it was found that polymer hydrophobicity (mol {\%} cetylation) controlled the nature of the self-assembly, giving micellar (cetyl groups < 23 mol {\%}), vesicular (cetyl groups = 23−42 mol {\%} or cetyl groups = 3−42 mol {\%} with cholesterol), and dense nanoparticle (cetyl groups ≥ 49 mol {\%}) aggregates. Thick (up to 15 nm) membranes due to the polyelectrolyte coating with the amphiphile were observed with low levels of cetylation only, and both dn/dc (indirectly) and vesicle/nanoparticle size (directly) varied linearly with mol {\%} cetylation (r = 0.96−0.99).",
keywords = "cetyl linear polyethylenimine , micelles, vesicles, nanoparticles",
author = "A. Gray",
year = "2004",
doi = "10.1021/ma049042o",
language = "English",
volume = "37",
pages = "9114--9122",
journal = "Macromolecules",
issn = "0024-9297",
publisher = "American Chemical Society",
number = "24",

}

Self-assembly of cetyl linear polyethylenimine to give micelles, vesicles, and dense nanoparticles. / Gray, A.

In: Macromolecules, Vol. 37, No. 24, 2004, p. 9114-9122.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Self-assembly of cetyl linear polyethylenimine to give micelles, vesicles, and dense nanoparticles

AU - Gray, A.

PY - 2004

Y1 - 2004

N2 - The involvement of macromolecules in the formation of biological and other membranes has important implications for structural biology and nanoengineering. Using cetyl polyethylenimines of varying molecular weight and hydrophobicity, it was found that polymer hydrophobicity (mol % cetylation) controlled the nature of the self-assembly, giving micellar (cetyl groups < 23 mol %), vesicular (cetyl groups = 23−42 mol % or cetyl groups = 3−42 mol % with cholesterol), and dense nanoparticle (cetyl groups ≥ 49 mol %) aggregates. Thick (up to 15 nm) membranes due to the polyelectrolyte coating with the amphiphile were observed with low levels of cetylation only, and both dn/dc (indirectly) and vesicle/nanoparticle size (directly) varied linearly with mol % cetylation (r = 0.96−0.99).

AB - The involvement of macromolecules in the formation of biological and other membranes has important implications for structural biology and nanoengineering. Using cetyl polyethylenimines of varying molecular weight and hydrophobicity, it was found that polymer hydrophobicity (mol % cetylation) controlled the nature of the self-assembly, giving micellar (cetyl groups < 23 mol %), vesicular (cetyl groups = 23−42 mol % or cetyl groups = 3−42 mol % with cholesterol), and dense nanoparticle (cetyl groups ≥ 49 mol %) aggregates. Thick (up to 15 nm) membranes due to the polyelectrolyte coating with the amphiphile were observed with low levels of cetylation only, and both dn/dc (indirectly) and vesicle/nanoparticle size (directly) varied linearly with mol % cetylation (r = 0.96−0.99).

KW - cetyl linear polyethylenimine

KW - micelles

KW - vesicles

KW - nanoparticles

U2 - 10.1021/ma049042o

DO - 10.1021/ma049042o

M3 - Article

VL - 37

SP - 9114

EP - 9122

JO - Macromolecules

T2 - Macromolecules

JF - Macromolecules

SN - 0024-9297

IS - 24

ER -