Abstract
Compounds that can gelate aqueous solutions offer an intriguing toolbox to create functional hydrogel materials for biomedical applications. Amphiphilic Janus dendrimers with low molecular weights can readily form self-assembled fibers at very low mass proportion (0.2 wt %) to create supramolecular hydrogels (G'≫G'') with outstanding mechanical properties and storage modulus of G'>1000 Pa. The G' value and gel melting temperature can be tuned by modulating the position or number of hydrophobic alkyl chains in the dendrimer structure; thus enabling exquisite control over the mesoscale material properties in these molecular assemblies. The gels are formed within seconds by simple injection of ethanol-solvated dendrimers into an aqueous solution. Cryogenic TEM, small-angle X-ray scattering, and SEM were used to confirm the fibrous structure morphology of the gels. Furthermore, the gels can be efficiently loaded with different bioactive cargo, such as active enzymes, peptides, or small-molecule drugs, to be used for sustained release in drug delivery.
| Language | English |
|---|---|
| Pages | 14433-14439 |
| Number of pages | 7 |
| Journal | Chemistry - A European Journal |
| Volume | 21 |
| Issue number | 41 |
| Early online date | 1 Jul 2015 |
| DOIs | |
| Publication status | Published - 5 Oct 2015 |
Fingerprint
Keywords
- dendrimers
- drug delivery systems
- drug liberation
- hydrogels
- hydrophobic and hydrophilic Interactions
- peptides
- surface-active agents
- supramolecular gels
- rheology
- amphiphiles
Cite this
}
Self-assembly of amphiphilic Janus dendrimers into mechanically robust supramolecular hydrogels for sustained drug release. / Nummelin, Sami; Liljeström, Ville; Saarikoski, Eve; Ropponen, Jarmo; Nykänen, Antti; Linko, Veikko; Seppälä, Jukka; Hirvonen, Jouni; Ikkala, Olli; Bimbo, Luis M.; Kostiainen, Mauri A.
In: Chemistry - A European Journal, Vol. 21, No. 41, 05.10.2015, p. 14433-14439.Research output: Contribution to journal › Article
TY - JOUR
T1 - Self-assembly of amphiphilic Janus dendrimers into mechanically robust supramolecular hydrogels for sustained drug release
AU - Nummelin, Sami
AU - Liljeström, Ville
AU - Saarikoski, Eve
AU - Ropponen, Jarmo
AU - Nykänen, Antti
AU - Linko, Veikko
AU - Seppälä, Jukka
AU - Hirvonen, Jouni
AU - Ikkala, Olli
AU - Bimbo, Luis M.
AU - Kostiainen, Mauri A
N1 - © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2015/10/5
Y1 - 2015/10/5
N2 - Compounds that can gelate aqueous solutions offer an intriguing toolbox to create functional hydrogel materials for biomedical applications. Amphiphilic Janus dendrimers with low molecular weights can readily form self-assembled fibers at very low mass proportion (0.2 wt %) to create supramolecular hydrogels (G'≫G'') with outstanding mechanical properties and storage modulus of G'>1000 Pa. The G' value and gel melting temperature can be tuned by modulating the position or number of hydrophobic alkyl chains in the dendrimer structure; thus enabling exquisite control over the mesoscale material properties in these molecular assemblies. The gels are formed within seconds by simple injection of ethanol-solvated dendrimers into an aqueous solution. Cryogenic TEM, small-angle X-ray scattering, and SEM were used to confirm the fibrous structure morphology of the gels. Furthermore, the gels can be efficiently loaded with different bioactive cargo, such as active enzymes, peptides, or small-molecule drugs, to be used for sustained release in drug delivery.
AB - Compounds that can gelate aqueous solutions offer an intriguing toolbox to create functional hydrogel materials for biomedical applications. Amphiphilic Janus dendrimers with low molecular weights can readily form self-assembled fibers at very low mass proportion (0.2 wt %) to create supramolecular hydrogels (G'≫G'') with outstanding mechanical properties and storage modulus of G'>1000 Pa. The G' value and gel melting temperature can be tuned by modulating the position or number of hydrophobic alkyl chains in the dendrimer structure; thus enabling exquisite control over the mesoscale material properties in these molecular assemblies. The gels are formed within seconds by simple injection of ethanol-solvated dendrimers into an aqueous solution. Cryogenic TEM, small-angle X-ray scattering, and SEM were used to confirm the fibrous structure morphology of the gels. Furthermore, the gels can be efficiently loaded with different bioactive cargo, such as active enzymes, peptides, or small-molecule drugs, to be used for sustained release in drug delivery.
KW - dendrimers
KW - drug delivery systems
KW - drug liberation
KW - hydrogels
KW - hydrophobic and hydrophilic Interactions
KW - peptides
KW - surface-active agents
KW - supramolecular gels
KW - rheology
KW - amphiphiles
U2 - 10.1002/chem.201501812
DO - 10.1002/chem.201501812
M3 - Article
VL - 21
SP - 14433
EP - 14439
JO - Chemistry - A European Journal
T2 - Chemistry - A European Journal
JF - Chemistry - A European Journal
SN - 0947-6539
IS - 41
ER -