Self-assembly of amphiphilic Janus dendrimers into mechanically robust supramolecular hydrogels for sustained drug release

Sami Nummelin, Ville Liljeström, Eve Saarikoski, Jarmo Ropponen, Antti Nykänen, Veikko Linko, Jukka Seppälä, Jouni Hirvonen, Olli Ikkala, Luis M. Bimbo, Mauri A Kostiainen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Compounds that can gelate aqueous solutions offer an intriguing toolbox to create functional hydrogel materials for biomedical applications. Amphiphilic Janus dendrimers with low molecular weights can readily form self-assembled fibers at very low mass proportion (0.2 wt %) to create supramolecular hydrogels (G'≫G'') with outstanding mechanical properties and storage modulus of G'>1000 Pa. The G' value and gel melting temperature can be tuned by modulating the position or number of hydrophobic alkyl chains in the dendrimer structure; thus enabling exquisite control over the mesoscale material properties in these molecular assemblies. The gels are formed within seconds by simple injection of ethanol-solvated dendrimers into an aqueous solution. Cryogenic TEM, small-angle X-ray scattering, and SEM were used to confirm the fibrous structure morphology of the gels. Furthermore, the gels can be efficiently loaded with different bioactive cargo, such as active enzymes, peptides, or small-molecule drugs, to be used for sustained release in drug delivery.

LanguageEnglish
Pages14433-14439
Number of pages7
JournalChemistry - A European Journal
Volume21
Issue number41
Early online date1 Jul 2015
DOIs
Publication statusPublished - 5 Oct 2015

Fingerprint

Dendrimers
Hydrogels
Self assembly
Gels
Pharmaceutical Preparations
Hydrogel
X ray scattering
Drug delivery
Cryogenics
Peptides
Melting point
Materials properties
Ethanol
Enzymes
Elastic moduli
Molecular weight
Transmission electron microscopy
Mechanical properties
Scanning electron microscopy
Molecules

Keywords

  • dendrimers
  • drug delivery systems
  • drug liberation
  • hydrogels
  • hydrophobic and hydrophilic Interactions
  • peptides
  • surface-active agents
  • supramolecular gels
  • rheology
  • amphiphiles

Cite this

Nummelin, S., Liljeström, V., Saarikoski, E., Ropponen, J., Nykänen, A., Linko, V., ... Kostiainen, M. A. (2015). Self-assembly of amphiphilic Janus dendrimers into mechanically robust supramolecular hydrogels for sustained drug release. Chemistry - A European Journal, 21(41), 14433-14439. https://doi.org/10.1002/chem.201501812
Nummelin, Sami ; Liljeström, Ville ; Saarikoski, Eve ; Ropponen, Jarmo ; Nykänen, Antti ; Linko, Veikko ; Seppälä, Jukka ; Hirvonen, Jouni ; Ikkala, Olli ; Bimbo, Luis M. ; Kostiainen, Mauri A. / Self-assembly of amphiphilic Janus dendrimers into mechanically robust supramolecular hydrogels for sustained drug release. In: Chemistry - A European Journal. 2015 ; Vol. 21, No. 41. pp. 14433-14439.
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abstract = "Compounds that can gelate aqueous solutions offer an intriguing toolbox to create functional hydrogel materials for biomedical applications. Amphiphilic Janus dendrimers with low molecular weights can readily form self-assembled fibers at very low mass proportion (0.2 wt {\%}) to create supramolecular hydrogels (G'≫G'') with outstanding mechanical properties and storage modulus of G'>1000 Pa. The G' value and gel melting temperature can be tuned by modulating the position or number of hydrophobic alkyl chains in the dendrimer structure; thus enabling exquisite control over the mesoscale material properties in these molecular assemblies. The gels are formed within seconds by simple injection of ethanol-solvated dendrimers into an aqueous solution. Cryogenic TEM, small-angle X-ray scattering, and SEM were used to confirm the fibrous structure morphology of the gels. Furthermore, the gels can be efficiently loaded with different bioactive cargo, such as active enzymes, peptides, or small-molecule drugs, to be used for sustained release in drug delivery.",
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Nummelin, S, Liljeström, V, Saarikoski, E, Ropponen, J, Nykänen, A, Linko, V, Seppälä, J, Hirvonen, J, Ikkala, O, Bimbo, LM & Kostiainen, MA 2015, 'Self-assembly of amphiphilic Janus dendrimers into mechanically robust supramolecular hydrogels for sustained drug release' Chemistry - A European Journal, vol. 21, no. 41, pp. 14433-14439. https://doi.org/10.1002/chem.201501812

Self-assembly of amphiphilic Janus dendrimers into mechanically robust supramolecular hydrogels for sustained drug release. / Nummelin, Sami; Liljeström, Ville; Saarikoski, Eve; Ropponen, Jarmo; Nykänen, Antti; Linko, Veikko; Seppälä, Jukka; Hirvonen, Jouni; Ikkala, Olli; Bimbo, Luis M.; Kostiainen, Mauri A.

In: Chemistry - A European Journal, Vol. 21, No. 41, 05.10.2015, p. 14433-14439.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Self-assembly of amphiphilic Janus dendrimers into mechanically robust supramolecular hydrogels for sustained drug release

AU - Nummelin, Sami

AU - Liljeström, Ville

AU - Saarikoski, Eve

AU - Ropponen, Jarmo

AU - Nykänen, Antti

AU - Linko, Veikko

AU - Seppälä, Jukka

AU - Hirvonen, Jouni

AU - Ikkala, Olli

AU - Bimbo, Luis M.

AU - Kostiainen, Mauri A

N1 - © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PY - 2015/10/5

Y1 - 2015/10/5

N2 - Compounds that can gelate aqueous solutions offer an intriguing toolbox to create functional hydrogel materials for biomedical applications. Amphiphilic Janus dendrimers with low molecular weights can readily form self-assembled fibers at very low mass proportion (0.2 wt %) to create supramolecular hydrogels (G'≫G'') with outstanding mechanical properties and storage modulus of G'>1000 Pa. The G' value and gel melting temperature can be tuned by modulating the position or number of hydrophobic alkyl chains in the dendrimer structure; thus enabling exquisite control over the mesoscale material properties in these molecular assemblies. The gels are formed within seconds by simple injection of ethanol-solvated dendrimers into an aqueous solution. Cryogenic TEM, small-angle X-ray scattering, and SEM were used to confirm the fibrous structure morphology of the gels. Furthermore, the gels can be efficiently loaded with different bioactive cargo, such as active enzymes, peptides, or small-molecule drugs, to be used for sustained release in drug delivery.

AB - Compounds that can gelate aqueous solutions offer an intriguing toolbox to create functional hydrogel materials for biomedical applications. Amphiphilic Janus dendrimers with low molecular weights can readily form self-assembled fibers at very low mass proportion (0.2 wt %) to create supramolecular hydrogels (G'≫G'') with outstanding mechanical properties and storage modulus of G'>1000 Pa. The G' value and gel melting temperature can be tuned by modulating the position or number of hydrophobic alkyl chains in the dendrimer structure; thus enabling exquisite control over the mesoscale material properties in these molecular assemblies. The gels are formed within seconds by simple injection of ethanol-solvated dendrimers into an aqueous solution. Cryogenic TEM, small-angle X-ray scattering, and SEM were used to confirm the fibrous structure morphology of the gels. Furthermore, the gels can be efficiently loaded with different bioactive cargo, such as active enzymes, peptides, or small-molecule drugs, to be used for sustained release in drug delivery.

KW - dendrimers

KW - drug delivery systems

KW - drug liberation

KW - hydrogels

KW - hydrophobic and hydrophilic Interactions

KW - peptides

KW - surface-active agents

KW - supramolecular gels

KW - rheology

KW - amphiphiles

U2 - 10.1002/chem.201501812

DO - 10.1002/chem.201501812

M3 - Article

VL - 21

SP - 14433

EP - 14439

JO - Chemistry - A European Journal

T2 - Chemistry - A European Journal

JF - Chemistry - A European Journal

SN - 0947-6539

IS - 41

ER -