Selective neuromuscular blocking properties of α-conotoxins In vivo

I. G. Marshall; A. L. Harvey

doi:10.1016/0041-0101(90)90417-6

Selective neuromuscular blocking properties of α-conotoxins In vivo

I. G. Marshall, A. L. Harvey^*

^*Corresponding author for this work

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Synthetic α-conotoxins GI and MI (based on the natural polypeptides isolated from Conus geographus and C. magus, respectively) were tested for effects on neuromuscular transmission and on the cardiovascular system in anaesthetised cats. Both produced neuromuscular blockade at doses of 20-80 μg/kg. Conotoxin GI was about 2.5 times more potent than MI. Both were rapidly reversed by the anticholinesterase neostigmine. At doses that abolished neuromuscular transmission, the α-conotoxins had no effects on arterial blood pressure, heart rate, or responses to vagal and preganglionic stimulation, indicating their specificity for nicotinic receptors at the neuromuscular junction.

Original language	English
Pages (from-to)	231-234
Number of pages	4
Journal	Toxicon
Volume	28
Issue number	2
DOIs	https://doi.org/10.1016/0041-0101(90)90417-6
Publication status	Published - 1 Jan 1990

Keywords

alpha conotoxin
neostigmine
nicotinic receptor
unclassified drug
vecuronium
animal experiment
cardiovascular system
neuromuscular blocking
mollusk venoms

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title = "Selective neuromuscular blocking properties of α-conotoxins In vivo",

abstract = "Synthetic α-conotoxins GI and MI (based on the natural polypeptides isolated from Conus geographus and C. magus, respectively) were tested for effects on neuromuscular transmission and on the cardiovascular system in anaesthetised cats. Both produced neuromuscular blockade at doses of 20-80 μg/kg. Conotoxin GI was about 2.5 times more potent than MI. Both were rapidly reversed by the anticholinesterase neostigmine. At doses that abolished neuromuscular transmission, the α-conotoxins had no effects on arterial blood pressure, heart rate, or responses to vagal and preganglionic stimulation, indicating their specificity for nicotinic receptors at the neuromuscular junction.",

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AU - Harvey, A. L.

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AB - Synthetic α-conotoxins GI and MI (based on the natural polypeptides isolated from Conus geographus and C. magus, respectively) were tested for effects on neuromuscular transmission and on the cardiovascular system in anaesthetised cats. Both produced neuromuscular blockade at doses of 20-80 μg/kg. Conotoxin GI was about 2.5 times more potent than MI. Both were rapidly reversed by the anticholinesterase neostigmine. At doses that abolished neuromuscular transmission, the α-conotoxins had no effects on arterial blood pressure, heart rate, or responses to vagal and preganglionic stimulation, indicating their specificity for nicotinic receptors at the neuromuscular junction.

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KW - neostigmine

KW - nicotinic receptor

KW - unclassified drug

KW - vecuronium

KW - animal experiment

KW - cardiovascular system

KW - neuromuscular blocking

KW - mollusk venoms

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Selective neuromuscular blocking properties of α-conotoxins In vivo

Abstract

Keywords

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