Selective monomethylation of anilines by Cu(OAc)2-promoted cross-coupling with MeB(OH)2

Israel González, Jesús Mosquera, César Guerrero, Ramón Rodríguez, Jacobo Cruces

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)


N-Methylanilines are readily synthesized in high yields through the copper(ll)-promoted coupling of anilines and methylboronic acid. This method represents a new approach for the selective monomethylation of anilines, and it is the first reported example of a Chan-Lam coupling involving the use of methylboronic acid. An incubation period of the substrate with the copper reagent is needed before addition of the methylboronic acid.

Original languageEnglish
Pages (from-to)1677-1680
Number of pages4
JournalOrganic Letters
Issue number8
Early online date20 Mar 2009
Publication statusPublished - 16 Apr 2009


  • N-Methylanilines
  • anilines
  • Chan-Lam coupling


Dive into the research topics of 'Selective monomethylation of anilines by Cu(OAc)<sub>2</sub>-promoted cross-coupling with MeB(OH)<sub>2</sub>'. Together they form a unique fingerprint.

Cite this