Selective inhibitors and allosteric activators of sphingosine kinase

Robert Bittman; Nigel Pyne; Susan Pyne; Dong Jae Baek; Zheng Liu; Hoe-Sup Byun

Selective inhibitors and allosteric activators of sphingosine kinase

Robert Bittman (Inventor), Nigel Pyne (Inventor), Susan Pyne (Inventor), Dong Jae Baek (Inventor), Zheng Liu (Inventor), Hoe-Sup Byun (Inventor)

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Patent

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Abstract

Sphingosine 1-phosphate (S1P) is involved in hyper-proliferative diseases, such as cancer and vascular remodeling in pulmonary arterial hypertension. Inhibitors of sphingosine kinase 1 and 2 (SK1 and SK2), which catalyze the synthesis of S1P, may be useful anti- proliferative agents. We have synthesized a series of sphingosine-based inhibitors of SK and SK2. Also provided in this invention are compounds that activate SK1 which can be used in diseases such as fibrosis, where intracellular S1P is anti-fibrotic.

Original language	English
Patent number	PCT/GB2014/050264
IPC	C07D401/04
Priority date	31/01/13
Publication status	Published - 7 Aug 2014

Keywords

inhibitors
synthesis
anti-proliferative agents

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Selective inhibitors and allosteric activators of sphingosine kinase",

abstract = "Sphingosine 1-phosphate (S1P) is involved in hyper-proliferative diseases, such as cancer and vascular remodeling in pulmonary arterial hypertension. Inhibitors of sphingosine kinase 1 and 2 (SK1 and SK2), which catalyze the synthesis of S1P, may be useful anti- proliferative agents. We have synthesized a series of sphingosine-based inhibitors of SK and SK2. Also provided in this invention are compounds that activate SK1 which can be used in diseases such as fibrosis, where intracellular S1P is anti-fibrotic.",

keywords = "inhibitors, synthesis, anti-proliferative agents",

author = "Robert Bittman and Nigel Pyne and Susan Pyne and Baek, {Dong Jae} and Zheng Liu and Hoe-Sup Byun",

year = "2014",

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language = "English",

type = "Patent",

note = "PCT/GB2014/050264; C07D401/04",

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TY - PAT

T1 - Selective inhibitors and allosteric activators of sphingosine kinase

AU - Bittman, Robert

AU - Pyne, Nigel

AU - Pyne, Susan

AU - Baek, Dong Jae

AU - Liu, Zheng

AU - Byun, Hoe-Sup

PY - 2014/8/7

Y1 - 2014/8/7

N2 - Sphingosine 1-phosphate (S1P) is involved in hyper-proliferative diseases, such as cancer and vascular remodeling in pulmonary arterial hypertension. Inhibitors of sphingosine kinase 1 and 2 (SK1 and SK2), which catalyze the synthesis of S1P, may be useful anti- proliferative agents. We have synthesized a series of sphingosine-based inhibitors of SK and SK2. Also provided in this invention are compounds that activate SK1 which can be used in diseases such as fibrosis, where intracellular S1P is anti-fibrotic.

AB - Sphingosine 1-phosphate (S1P) is involved in hyper-proliferative diseases, such as cancer and vascular remodeling in pulmonary arterial hypertension. Inhibitors of sphingosine kinase 1 and 2 (SK1 and SK2), which catalyze the synthesis of S1P, may be useful anti- proliferative agents. We have synthesized a series of sphingosine-based inhibitors of SK and SK2. Also provided in this invention are compounds that activate SK1 which can be used in diseases such as fibrosis, where intracellular S1P is anti-fibrotic.

KW - inhibitors

KW - synthesis

KW - anti-proliferative agents

UR - http://patentscope.wipo.int/search/en/WO2014118556

M3 - Patent

M1 - PCT/GB2014/050264

ER -

Selective inhibitors and allosteric activators of sphingosine kinase

Abstract

Keywords

UN SDGs

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