Selective inhibitors and allosteric activators of sphingosine kinase

Robert Bittman (Inventor), Nigel Pyne (Inventor), Susan Pyne (Inventor), Dong Jae Baek (Inventor), Zheng Liu (Inventor), Hoe-Sup Byun (Inventor)

Research output: Patent

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Sphingosine 1-phosphate (S1P) is involved in hyper-proliferative diseases, such as cancer and vascular remodeling in pulmonary arterial hypertension. Inhibitors of sphingosine kinase 1 and 2 (SK1 and SK2), which catalyze the synthesis of S1P, may be useful anti- proliferative agents. We have synthesized a series of sphingosine-based inhibitors of SK and SK2. Also provided in this invention are compounds that activate SK1 which can be used in diseases such as fibrosis, where intracellular S1P is anti-fibrotic.
Original languageEnglish
Patent numberPCT/GB2014/050264
Priority date31/01/13
Publication statusPublished - 7 Aug 2014


  • inhibitors
  • synthesis
  • anti-proliferative agents


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