Selective and responsive nanoreactors

Kasper Renggli, Patric Baumann, Karolina Langowska, Ozana Onaca, Nico Bruns, Wolfgang Meier

Research output: Contribution to journalArticle

147 Citations (Scopus)

Abstract

Chemical reactions can be confined to nanoscale compartments by encapsulating catalysts in hollow nanoobjects. Such reaction compartments effectively become nanoreactors when substrate and product are exchanged between bulk solution and cavity. A key issue, thereby, is control of shell permeability. Nanoreactors exhibit selectivity and responsiveness if their shells discriminate among molecules and if access can be modulated by external triggers. Here, we review natural nanoreactors that include protein-based bacterial microcompartments, protein cages, and viruses. Artificial nanoreactors based on dendrimers, layer-by-layer capsules, and amphiphilic block copolymer polymersomes are also discussed. Selectivity in these nanoreactors is either due to intrinsic reactor-shell semipermeability or can be engineered using smart polymers to gate the reactors. Moreover, a rich repertoire of pores and channels are already provided in nature, e.g., in protein-based nanoreactors or in trans-membrane channel proteins. The latter can be reconstituted in polymersomes, resulting in gated vesicles. Nanoreactors hold promise for applications ranging from selective and size-constrained organic synthesis to biomedical advances (e.g., artificial organelles, biosensing) and as analytical tools to study reaction mechanisms. Nanoreactors that discriminate between molecules as well as strategies to modulate access by external triggers are reviewed. The covered systems include nature's nanoreactors such as protein-based microcompartments, protein cages, and viruses, as well as artificial and biomimetic systems such as polymersomes equipped with channel proteins, dendrimers, and layer-by-layer capsules.

LanguageEnglish
Pages1241-1259
Number of pages19
JournalAdvanced Functional Materials
Volume21
Issue number7
DOIs
Publication statusPublished - 8 Apr 2011

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Nanoreactors
proteins
Proteins
dendrimers
viruses
compartments
capsules
Dendrimers
Viruses
actuators
selectivity
reactors
Capsules
organelles
encapsulating
biomimetics
block copolymers
Molecules
Bacterial Proteins
molecules

Keywords

  • dendrimers
  • layer-by-layer capsules
  • membrane proteins
  • polymersomes
  • protein cages

Cite this

Renggli, K., Baumann, P., Langowska, K., Onaca, O., Bruns, N., & Meier, W. (2011). Selective and responsive nanoreactors. Advanced Functional Materials, 21(7), 1241-1259. https://doi.org/10.1002/adfm.201001563
Renggli, Kasper ; Baumann, Patric ; Langowska, Karolina ; Onaca, Ozana ; Bruns, Nico ; Meier, Wolfgang. / Selective and responsive nanoreactors. In: Advanced Functional Materials. 2011 ; Vol. 21, No. 7. pp. 1241-1259.
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Renggli, K, Baumann, P, Langowska, K, Onaca, O, Bruns, N & Meier, W 2011, 'Selective and responsive nanoreactors' Advanced Functional Materials, vol. 21, no. 7, pp. 1241-1259. https://doi.org/10.1002/adfm.201001563

Selective and responsive nanoreactors. / Renggli, Kasper; Baumann, Patric; Langowska, Karolina; Onaca, Ozana; Bruns, Nico; Meier, Wolfgang.

In: Advanced Functional Materials, Vol. 21, No. 7, 08.04.2011, p. 1241-1259.

Research output: Contribution to journalArticle

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Renggli K, Baumann P, Langowska K, Onaca O, Bruns N, Meier W. Selective and responsive nanoreactors. Advanced Functional Materials. 2011 Apr 8;21(7):1241-1259. https://doi.org/10.1002/adfm.201001563