Selection of tetracycline and ampicillin resistance genes during long-term soil-copper exposure

Seanin McCluskey, Charles W. Knapp

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Antibiotic resistance is an issue of paramount clinical concern. While the overuse of antibiotics is the much touted cause of the current resistance issue we face, the problem is in fact much more complex than that. The role of the environment and selection pressures present have been known to be contributing factors to the cycling and maintenance of antibiotic resistance genes for some time. The specific details of the link between the environment and clinical setting are still being elucidated and may prove to be vital in staving off the ever approaching post-antibiotic era we face. Metals in the environment, for example, could be a significant factor in the development of antibiotic resistance. Here, we assessed the contribution of elevated levels of copper on the selection of ampicillin and tetracycline resistance in soils. Tetracycline resistance genes, particularly those conferring resistance via efflux mechanisms, had higher relative abundances upon exposure to copper over time; whereas, ampicillin resistance genes showed marginal differences among treatments. Overall, the presence of copper into the environment does pose a risk with regards to the increase and maintenance of antibiotic resistance. The environment and metals present should be considered when devising policy to tackle the antibiotic resistance issue.
LanguageEnglish
Title of host publicationAntibiotic Resistance Genes in Natural Environments and Long-Term Effects
EditorsSalvador Mirete
Place of PublicationNew York
Pages199-216
Number of pages17
Publication statusPublished - 16 May 2017

Fingerprint

Antibiotics
Genes
Copper
Soils
Metals

Keywords

  • tetracycline
  • ampicillin
  • copper
  • resistance

Cite this

McCluskey, S., & Knapp, C. W. (2017). Selection of tetracycline and ampicillin resistance genes during long-term soil-copper exposure. In S. Mirete (Ed.), Antibiotic Resistance Genes in Natural Environments and Long-Term Effects (pp. 199-216). New York.
McCluskey, Seanin ; Knapp, Charles W. / Selection of tetracycline and ampicillin resistance genes during long-term soil-copper exposure. Antibiotic Resistance Genes in Natural Environments and Long-Term Effects. editor / Salvador Mirete. New York, 2017. pp. 199-216
@inbook{f0b82fc65db240848764fb4ff395e5c9,
title = "Selection of tetracycline and ampicillin resistance genes during long-term soil-copper exposure",
abstract = "Antibiotic resistance is an issue of paramount clinical concern. While the overuse of antibiotics is the much touted cause of the current resistance issue we face, the problem is in fact much more complex than that. The role of the environment and selection pressures present have been known to be contributing factors to the cycling and maintenance of antibiotic resistance genes for some time. The specific details of the link between the environment and clinical setting are still being elucidated and may prove to be vital in staving off the ever approaching post-antibiotic era we face. Metals in the environment, for example, could be a significant factor in the development of antibiotic resistance. Here, we assessed the contribution of elevated levels of copper on the selection of ampicillin and tetracycline resistance in soils. Tetracycline resistance genes, particularly those conferring resistance via efflux mechanisms, had higher relative abundances upon exposure to copper over time; whereas, ampicillin resistance genes showed marginal differences among treatments. Overall, the presence of copper into the environment does pose a risk with regards to the increase and maintenance of antibiotic resistance. The environment and metals present should be considered when devising policy to tackle the antibiotic resistance issue.",
keywords = "tetracycline, ampicillin, copper, resistance",
author = "Seanin McCluskey and Knapp, {Charles W.}",
year = "2017",
month = "5",
day = "16",
language = "English",
isbn = "978-1-53611-818-6",
pages = "199--216",
editor = "Salvador Mirete",
booktitle = "Antibiotic Resistance Genes in Natural Environments and Long-Term Effects",

}

McCluskey, S & Knapp, CW 2017, Selection of tetracycline and ampicillin resistance genes during long-term soil-copper exposure. in S Mirete (ed.), Antibiotic Resistance Genes in Natural Environments and Long-Term Effects. New York, pp. 199-216.

Selection of tetracycline and ampicillin resistance genes during long-term soil-copper exposure. / McCluskey, Seanin; Knapp, Charles W.

Antibiotic Resistance Genes in Natural Environments and Long-Term Effects. ed. / Salvador Mirete. New York, 2017. p. 199-216.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Selection of tetracycline and ampicillin resistance genes during long-term soil-copper exposure

AU - McCluskey, Seanin

AU - Knapp, Charles W.

PY - 2017/5/16

Y1 - 2017/5/16

N2 - Antibiotic resistance is an issue of paramount clinical concern. While the overuse of antibiotics is the much touted cause of the current resistance issue we face, the problem is in fact much more complex than that. The role of the environment and selection pressures present have been known to be contributing factors to the cycling and maintenance of antibiotic resistance genes for some time. The specific details of the link between the environment and clinical setting are still being elucidated and may prove to be vital in staving off the ever approaching post-antibiotic era we face. Metals in the environment, for example, could be a significant factor in the development of antibiotic resistance. Here, we assessed the contribution of elevated levels of copper on the selection of ampicillin and tetracycline resistance in soils. Tetracycline resistance genes, particularly those conferring resistance via efflux mechanisms, had higher relative abundances upon exposure to copper over time; whereas, ampicillin resistance genes showed marginal differences among treatments. Overall, the presence of copper into the environment does pose a risk with regards to the increase and maintenance of antibiotic resistance. The environment and metals present should be considered when devising policy to tackle the antibiotic resistance issue.

AB - Antibiotic resistance is an issue of paramount clinical concern. While the overuse of antibiotics is the much touted cause of the current resistance issue we face, the problem is in fact much more complex than that. The role of the environment and selection pressures present have been known to be contributing factors to the cycling and maintenance of antibiotic resistance genes for some time. The specific details of the link between the environment and clinical setting are still being elucidated and may prove to be vital in staving off the ever approaching post-antibiotic era we face. Metals in the environment, for example, could be a significant factor in the development of antibiotic resistance. Here, we assessed the contribution of elevated levels of copper on the selection of ampicillin and tetracycline resistance in soils. Tetracycline resistance genes, particularly those conferring resistance via efflux mechanisms, had higher relative abundances upon exposure to copper over time; whereas, ampicillin resistance genes showed marginal differences among treatments. Overall, the presence of copper into the environment does pose a risk with regards to the increase and maintenance of antibiotic resistance. The environment and metals present should be considered when devising policy to tackle the antibiotic resistance issue.

KW - tetracycline

KW - ampicillin

KW - copper

KW - resistance

UR - https://www.novapublishers.com/catalog/product_info.php?products_id=61602

M3 - Chapter

SN - 978-1-53611-818-6

SP - 199

EP - 216

BT - Antibiotic Resistance Genes in Natural Environments and Long-Term Effects

A2 - Mirete, Salvador

CY - New York

ER -

McCluskey S, Knapp CW. Selection of tetracycline and ampicillin resistance genes during long-term soil-copper exposure. In Mirete S, editor, Antibiotic Resistance Genes in Natural Environments and Long-Term Effects. New York. 2017. p. 199-216