Seeded crystallization of β-L-glutamic acid in a continuous oscillatory baffled crystallizer

Naomi E. B. Briggs, Ulrich Schacht, Vishal Raval, Thomas McGlone, Jan Sefcik, Alastair J. Florence

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

A continuously seeded l-glutamic acid cooling crystallization process, in a continuous oscillatory baffled crystallizer, was designed and operated to deliver control over polymorphic form. Different feed solution concentrations and seed loadings of β-l-glutamic acid crystals were examined. Steady-state operation, based on particle size distribution and polymorphic form, was demonstrated consistently after two residence times. Where bulk supersaturation remained in the range 2–3, the polymorphic phase purity of the thermodynamically stable β polymorph was retained. However, when the bulk supersaturation exceeded this range to values of 3–8, primary nucleation of the metastable α polymorph was observed, and product crystals were a mixed phase. In the absence of seeding the system could not be operated without significant encrustation to the vessel surface thus leading to loss of control, whereas a continuously seeded approach allowed robust processing for at least 10 h.
LanguageEnglish
Pages1903−1911
Number of pages9
JournalOrganic Process Research and Development
Volume19
Issue number12
Early online date12 Oct 2015
DOIs
Publication statusPublished - 18 Dec 2015

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Crystallizers
glutamic acid
Supersaturation
Crystallization
supersaturation
Polymorphism
Particle Size
Glutamic Acid
Seeds
crystallization
Crystals
inoculation
particle size distribution
Particle size analysis
crystals
vessels
Seed
seeds
purity
Nucleation

Keywords

  • crystallization process
  • β-l-glutamic acid crystals
  • continuous oscillatory baffled crystallizer

Cite this

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abstract = "A continuously seeded l-glutamic acid cooling crystallization process, in a continuous oscillatory baffled crystallizer, was designed and operated to deliver control over polymorphic form. Different feed solution concentrations and seed loadings of β-l-glutamic acid crystals were examined. Steady-state operation, based on particle size distribution and polymorphic form, was demonstrated consistently after two residence times. Where bulk supersaturation remained in the range 2–3, the polymorphic phase purity of the thermodynamically stable β polymorph was retained. However, when the bulk supersaturation exceeded this range to values of 3–8, primary nucleation of the metastable α polymorph was observed, and product crystals were a mixed phase. In the absence of seeding the system could not be operated without significant encrustation to the vessel surface thus leading to loss of control, whereas a continuously seeded approach allowed robust processing for at least 10 h.",
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Seeded crystallization of β-L-glutamic acid in a continuous oscillatory baffled crystallizer. / Briggs, Naomi E. B.; Schacht, Ulrich; Raval, Vishal; McGlone, Thomas; Sefcik, Jan; Florence, Alastair J.

In: Organic Process Research and Development, Vol. 19, No. 12, 18.12.2015, p. 1903−1911.

Research output: Contribution to journalArticle

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AU - Schacht, Ulrich

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AU - Florence, Alastair J.

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