Secondary metabolites isolated from the strain Aspergillus terreus

In this research we isolated three natural compounds from a strain of Aspergillus terreus collected from “paramo de Guasca (Cundinamarca, Colombia).” The A. terreus was fermented in PGS and Saboraud media at room temperature for 12 days. The biomass obtained (36.5 g) was extracted by the Soxhlet method (hexane, CH2Cl2, EtOAc, and MeOH). The MeOH extract was chromatographed on silica gel 60 G and eluted in a mixture of EtOAc–MeOH 1:1. The mannitol (1) (180 mg) was isolated. The Sabouraud broth fermentation medium (20 L) was treated with hexane, CH2Cl2, and EtOAc. The CH2Cl2 extract was chromatographed on silica gel CC, and from the hexane– EtOAc 1:1 fraction, butyrolactone I (2) (40 mg) and R(–)-6-hydroxymellein (3) (8 mg) were isolated.