Seasonal 25-hydroxyvitamin D changes in British postmenopausal women at 57°N and 51°N: a longitudinal study

A. Mavroeidi, F. O'Neill, P. A. Lee, A. L. Darling, W. D. Fraser, J. L. Berry, W. T. Lee, D. M. Reid, S. A. Lanham-New, H. M. Macdonald

Research output: Contribution to journalArticle

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Abstract

The UK has insufficient intensity of sunlight at wavelengths 290-315. nm to enable cutaneous synthesis of vitamin D from October to April. There are regional differences in UVB strength throughout the UK but whether this translates to differences in vitamin D status is not known. We have reported seasonal variations in a cross-sectional study of over 3000 Scottish women in Aberdeen. The aim of this longitudinal study was to compare the seasonal variation of serum 25-hydroxyvitamin D [25(OH)D] in postmenopausal women residing in Aberdeen (57°N) and Surrey (51°N). Women attended 3-monthly visits over 12 months, starting summer 2006. In Aberdeen, 338 Caucasian women (mean age ± SD, 61.7 ± 1.5 years); and at Surrey, 138 Caucasian women (61.4 ± 4.5 years) and 35 Asian women (59.9 ± 6.4 years) had serum 25(OH)D measured by IDS enzyme immunoassay. In winter/spring none of the Caucasian women living in Surrey had 25(OH)D < 20 nmol/L, but nearly a quarter of women in Aberdeen were vitamin D-deficient. This number decreased to 4.2% in summer/autumn. For the Asian women 17.1% were vitamin D-deficient in summer, increasing to 58.1% in winter. Using higher 25(OH)D deficiency cut-offs, the percentage of women affected was much higher. These longitudinal data show clear differences in vitamin D status between the north and south of the UK, and marked ethnic differences. They are consistent with our previous data and with cross-sectional data from the 1958 birth cohort. The low vitamin D status may have implications for bone health and other health outcomes, which is currently being investigated in this publication group. The extent of vitamin D deficiency in Asian women residing in the South of England is of concern.

LanguageEnglish
Pages459-461
Number of pages3
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume121
Issue number1-2
DOIs
Publication statusPublished - 1 Jul 2010

Fingerprint

Vitamin D
Longitudinal Studies
Health
25-hydroxyvitamin D
Bone
Vitamin D Deficiency
Sunlight
Serum
Immunoenzyme Techniques
Wavelength
England
Enzymes
Cross-Sectional Studies
Parturition
Bone and Bones
Skin

Keywords

  • asian vs. caucasian postmenopausal women
  • longitudinal study
  • regional UK variation
  • seasonal variation
  • vitamin D deficiency

Cite this

Mavroeidi, A. ; O'Neill, F. ; Lee, P. A. ; Darling, A. L. ; Fraser, W. D. ; Berry, J. L. ; Lee, W. T. ; Reid, D. M. ; Lanham-New, S. A. ; Macdonald, H. M. . / Seasonal 25-hydroxyvitamin D changes in British postmenopausal women at 57°N and 51°N : a longitudinal study. In: Journal of Steroid Biochemistry and Molecular Biology . 2010 ; Vol. 121, No. 1-2. pp. 459-461.
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abstract = "The UK has insufficient intensity of sunlight at wavelengths 290-315. nm to enable cutaneous synthesis of vitamin D from October to April. There are regional differences in UVB strength throughout the UK but whether this translates to differences in vitamin D status is not known. We have reported seasonal variations in a cross-sectional study of over 3000 Scottish women in Aberdeen. The aim of this longitudinal study was to compare the seasonal variation of serum 25-hydroxyvitamin D [25(OH)D] in postmenopausal women residing in Aberdeen (57°N) and Surrey (51°N). Women attended 3-monthly visits over 12 months, starting summer 2006. In Aberdeen, 338 Caucasian women (mean age ± SD, 61.7 ± 1.5 years); and at Surrey, 138 Caucasian women (61.4 ± 4.5 years) and 35 Asian women (59.9 ± 6.4 years) had serum 25(OH)D measured by IDS enzyme immunoassay. In winter/spring none of the Caucasian women living in Surrey had 25(OH)D < 20 nmol/L, but nearly a quarter of women in Aberdeen were vitamin D-deficient. This number decreased to 4.2{\%} in summer/autumn. For the Asian women 17.1{\%} were vitamin D-deficient in summer, increasing to 58.1{\%} in winter. Using higher 25(OH)D deficiency cut-offs, the percentage of women affected was much higher. These longitudinal data show clear differences in vitamin D status between the north and south of the UK, and marked ethnic differences. They are consistent with our previous data and with cross-sectional data from the 1958 birth cohort. The low vitamin D status may have implications for bone health and other health outcomes, which is currently being investigated in this publication group. The extent of vitamin D deficiency in Asian women residing in the South of England is of concern.",
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Mavroeidi, A, O'Neill, F, Lee, PA, Darling, AL, Fraser, WD, Berry, JL, Lee, WT, Reid, DM, Lanham-New, SA & Macdonald, HM 2010, 'Seasonal 25-hydroxyvitamin D changes in British postmenopausal women at 57°N and 51°N: a longitudinal study' Journal of Steroid Biochemistry and Molecular Biology , vol. 121, no. 1-2, pp. 459-461. https://doi.org/10.1016/j.jsbmb.2010.03.038

Seasonal 25-hydroxyvitamin D changes in British postmenopausal women at 57°N and 51°N : a longitudinal study. / Mavroeidi, A.; O'Neill, F.; Lee, P. A.; Darling, A. L.; Fraser, W. D.; Berry, J. L.; Lee, W. T.; Reid, D. M.; Lanham-New, S. A.; Macdonald, H. M. .

In: Journal of Steroid Biochemistry and Molecular Biology , Vol. 121, No. 1-2, 01.07.2010, p. 459-461.

Research output: Contribution to journalArticle

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AU - Lee, P. A.

AU - Darling, A. L.

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AU - Lee, W. T.

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AU - Lanham-New, S. A.

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