SeaBioTech

from sea-bed to test-bed : harvesting the potential of marine biodiversity for industrial biotechnology

Lynsey MacIntyre, Tong Zhang, Christina Victoria Viegelmann, Cheng Cheng, Dominick Perrocco, Catherine Dowdells, Ute Hentschel-Humeida, Usama Ramada Abdelmohsen, Ignacio Juarez Martinez, Olivia Moss, Ruangelie Edrada-Ebel

Research output: Contribution to conferencePoster

Abstract

SeaBioTech is an EU-FP7 project designed and driven by SMEs to create innovative marine biodiscovery pipelines as a means to convert the potential of marine biotechnology into novel industrial products for the pharmaceutical (human and aquaculture), cosmetic, functional food and industrial chemistry sectors. Sponges are a rich source of novel metabolites that are of medicinal interest particularly as anticancer compounds. However, it is not economically viable to target sponges as sources of commercial quantities of metabolites of interest. Sponge-associated endosymbiotic bacteria produce a plethora of novel secondary metabolites which may be structurally unique with interesting pharmacological properties. These metabolites can be produced in large quantities on a biotechnological scale without the need to harvest the sponge. As a case study for SeaBioTech the metabolomic methods of dereplication and metabolic profiling were used to identify pharmacologically relevant secondary metabolites from sponge-associated endosymbiotic bacteria from marine salt water sponges using LC-FTMS and NMR spectroscopy.
Original languageEnglish
Publication statusPublished - Sep 2013
Event14th International Symposium on Marine Natural Products and 8th European Conference on Marine Natural Products - La Toja, Spain
Duration: 15 Sep 201320 Sep 2013

Conference

Conference14th International Symposium on Marine Natural Products and 8th European Conference on Marine Natural Products
CountrySpain
CityLa Toja
Period15/09/1320/09/13

Fingerprint

Biodiversity
Porifera
Biotechnology
Oceans and Seas
Bacteria
Aquaculture
Functional Food
Metabolomics
Cosmetics
Magnetic Resonance Spectroscopy
Salts
Pharmacology
Water
Pharmaceutical Preparations

Keywords

  • SeaBioTech
  • marine biodiscovery pipelines
  • marine biotechnology
  • sponges
  • metabolites
  • anticancer compounds
  • metabolomic methods

Cite this

MacIntyre, L., Zhang, T., Viegelmann, C. V., Cheng, C., Perrocco, D., Dowdells, C., ... Edrada-Ebel, R. (2013). SeaBioTech: from sea-bed to test-bed : harvesting the potential of marine biodiversity for industrial biotechnology. Poster session presented at 14th International Symposium on Marine Natural Products and 8th European Conference on Marine Natural Products, La Toja, Spain.
MacIntyre, Lynsey ; Zhang, Tong ; Viegelmann, Christina Victoria ; Cheng, Cheng ; Perrocco, Dominick ; Dowdells, Catherine ; Hentschel-Humeida, Ute ; Abdelmohsen, Usama Ramada ; Martinez, Ignacio Juarez ; Moss, Olivia ; Edrada-Ebel, Ruangelie. / SeaBioTech : from sea-bed to test-bed : harvesting the potential of marine biodiversity for industrial biotechnology. Poster session presented at 14th International Symposium on Marine Natural Products and 8th European Conference on Marine Natural Products, La Toja, Spain.
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title = "SeaBioTech: from sea-bed to test-bed : harvesting the potential of marine biodiversity for industrial biotechnology",
abstract = "SeaBioTech is an EU-FP7 project designed and driven by SMEs to create innovative marine biodiscovery pipelines as a means to convert the potential of marine biotechnology into novel industrial products for the pharmaceutical (human and aquaculture), cosmetic, functional food and industrial chemistry sectors. Sponges are a rich source of novel metabolites that are of medicinal interest particularly as anticancer compounds. However, it is not economically viable to target sponges as sources of commercial quantities of metabolites of interest. Sponge-associated endosymbiotic bacteria produce a plethora of novel secondary metabolites which may be structurally unique with interesting pharmacological properties. These metabolites can be produced in large quantities on a biotechnological scale without the need to harvest the sponge. As a case study for SeaBioTech the metabolomic methods of dereplication and metabolic profiling were used to identify pharmacologically relevant secondary metabolites from sponge-associated endosymbiotic bacteria from marine salt water sponges using LC-FTMS and NMR spectroscopy.",
keywords = "SeaBioTech, marine biodiscovery pipelines, marine biotechnology, sponges, metabolites, anticancer compounds, metabolomic methods",
author = "Lynsey MacIntyre and Tong Zhang and Viegelmann, {Christina Victoria} and Cheng Cheng and Dominick Perrocco and Catherine Dowdells and Ute Hentschel-Humeida and Abdelmohsen, {Usama Ramada} and Martinez, {Ignacio Juarez} and Olivia Moss and Ruangelie Edrada-Ebel",
year = "2013",
month = "9",
language = "English",
note = "14th International Symposium on Marine Natural Products and 8th European Conference on Marine Natural Products ; Conference date: 15-09-2013 Through 20-09-2013",

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MacIntyre, L, Zhang, T, Viegelmann, CV, Cheng, C, Perrocco, D, Dowdells, C, Hentschel-Humeida, U, Abdelmohsen, UR, Martinez, IJ, Moss, O & Edrada-Ebel, R 2013, 'SeaBioTech: from sea-bed to test-bed : harvesting the potential of marine biodiversity for industrial biotechnology' 14th International Symposium on Marine Natural Products and 8th European Conference on Marine Natural Products, La Toja, Spain, 15/09/13 - 20/09/13, .

SeaBioTech : from sea-bed to test-bed : harvesting the potential of marine biodiversity for industrial biotechnology. / MacIntyre, Lynsey; Zhang, Tong; Viegelmann, Christina Victoria; Cheng, Cheng; Perrocco, Dominick; Dowdells, Catherine; Hentschel-Humeida, Ute; Abdelmohsen, Usama Ramada; Martinez, Ignacio Juarez; Moss, Olivia; Edrada-Ebel, Ruangelie.

2013. Poster session presented at 14th International Symposium on Marine Natural Products and 8th European Conference on Marine Natural Products, La Toja, Spain.

Research output: Contribution to conferencePoster

TY - CONF

T1 - SeaBioTech

T2 - from sea-bed to test-bed : harvesting the potential of marine biodiversity for industrial biotechnology

AU - MacIntyre, Lynsey

AU - Zhang, Tong

AU - Viegelmann, Christina Victoria

AU - Cheng, Cheng

AU - Perrocco, Dominick

AU - Dowdells, Catherine

AU - Hentschel-Humeida, Ute

AU - Abdelmohsen, Usama Ramada

AU - Martinez, Ignacio Juarez

AU - Moss, Olivia

AU - Edrada-Ebel, Ruangelie

PY - 2013/9

Y1 - 2013/9

N2 - SeaBioTech is an EU-FP7 project designed and driven by SMEs to create innovative marine biodiscovery pipelines as a means to convert the potential of marine biotechnology into novel industrial products for the pharmaceutical (human and aquaculture), cosmetic, functional food and industrial chemistry sectors. Sponges are a rich source of novel metabolites that are of medicinal interest particularly as anticancer compounds. However, it is not economically viable to target sponges as sources of commercial quantities of metabolites of interest. Sponge-associated endosymbiotic bacteria produce a plethora of novel secondary metabolites which may be structurally unique with interesting pharmacological properties. These metabolites can be produced in large quantities on a biotechnological scale without the need to harvest the sponge. As a case study for SeaBioTech the metabolomic methods of dereplication and metabolic profiling were used to identify pharmacologically relevant secondary metabolites from sponge-associated endosymbiotic bacteria from marine salt water sponges using LC-FTMS and NMR spectroscopy.

AB - SeaBioTech is an EU-FP7 project designed and driven by SMEs to create innovative marine biodiscovery pipelines as a means to convert the potential of marine biotechnology into novel industrial products for the pharmaceutical (human and aquaculture), cosmetic, functional food and industrial chemistry sectors. Sponges are a rich source of novel metabolites that are of medicinal interest particularly as anticancer compounds. However, it is not economically viable to target sponges as sources of commercial quantities of metabolites of interest. Sponge-associated endosymbiotic bacteria produce a plethora of novel secondary metabolites which may be structurally unique with interesting pharmacological properties. These metabolites can be produced in large quantities on a biotechnological scale without the need to harvest the sponge. As a case study for SeaBioTech the metabolomic methods of dereplication and metabolic profiling were used to identify pharmacologically relevant secondary metabolites from sponge-associated endosymbiotic bacteria from marine salt water sponges using LC-FTMS and NMR spectroscopy.

KW - SeaBioTech

KW - marine biodiscovery pipelines

KW - marine biotechnology

KW - sponges

KW - metabolites

KW - anticancer compounds

KW - metabolomic methods

M3 - Poster

ER -

MacIntyre L, Zhang T, Viegelmann CV, Cheng C, Perrocco D, Dowdells C et al. SeaBioTech: from sea-bed to test-bed : harvesting the potential of marine biodiversity for industrial biotechnology. 2013. Poster session presented at 14th International Symposium on Marine Natural Products and 8th European Conference on Marine Natural Products, La Toja, Spain.