Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation

Kirsty Wilson, Alan Kennedy, Jane Murray, Ben Greatex, Craig Jamieson, Allan Watson

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Pd-catalysed C-C bond formation is an essential tool within the pharmaceutical and agrochemical industries. Many of these reactions rely heavily on polar aprotic solvents; however, despite their utility, these solvents are incompatible with the drive towards more sustainable chemical synthesis. Herein, we describe the scope and limitations of an alternative to DMF derived from renewable sources (CyreneTM) in Sonogashira crosscoupling and Cacchi-type annulations.
LanguageEnglish
Pages2005-2011
Number of pages7
JournalBeilstein Journal of Organic Chemistry
Volume12
DOIs
Publication statusPublished - 8 Sep 2016

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Agrochemicals
Pharmaceutical Preparations
Industry

Keywords

  • Cacchi annulation
  • cross-coupling
  • heterocycles
  • Sonogashira
  • sustainable solvent
  • renewable sources
  • dipolar aprotic solvents
  • solvent replacement

Cite this

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Scope and limitations of a DMF bio-alternative within Sonogashira cross-coupling and Cacchi-type annulation. / Wilson, Kirsty; Kennedy, Alan; Murray, Jane; Greatex, Ben; Jamieson, Craig; Watson, Allan.

In: Beilstein Journal of Organic Chemistry , Vol. 12, 08.09.2016, p. 2005-2011.

Research output: Contribution to journalArticle

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AU - Watson, Allan

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KW - dipolar aprotic solvents

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