Schemes of flux control in a model of Saccharomyces cerevisiae glycolysis

Leighton Pritchard, Douglas B. Kell

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

We used parameter scanning to emulate changes to the limiting rate for steps in a fitted model of glucose-derepressed yeast glycolysis. Three flux-control regimes were observed, two of which were under the dominant control of hexose transport, in accordance with various experimental studies and other model predictions. A third control regime in which phosphofructokinase exerted dominant glycolytic flux control was also found, but it appeared to be physiologically unreachable by this model, and all realistically obtainable flux control regimes featured hexose transport as a step involving high flux control.

LanguageEnglish
Pages3894-3904
Number of pages11
JournalEuropean Journal of Biochemistry
Volume269
Issue number16
DOIs
Publication statusPublished - 31 Aug 2002

Fingerprint

Hexoses
Glycolysis
Yeast
Saccharomyces cerevisiae
Fluxes
Phosphofructokinases
Yeasts
Glucose
Scanning

Keywords

  • flux
  • glycolysis
  • metabolic control analysis
  • modelling
  • yeast

Cite this

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Schemes of flux control in a model of Saccharomyces cerevisiae glycolysis. / Pritchard, Leighton; Kell, Douglas B.

In: European Journal of Biochemistry , Vol. 269, No. 16, 31.08.2002, p. 3894-3904.

Research output: Contribution to journalArticle

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