Abstract
We used parameter scanning to emulate changes to the limiting rate for steps in a fitted model of glucose-derepressed yeast glycolysis. Three flux-control regimes were observed, two of which were under the dominant control of hexose transport, in accordance with various experimental studies and other model predictions. A third control regime in which phosphofructokinase exerted dominant glycolytic flux control was also found, but it appeared to be physiologically unreachable by this model, and all realistically obtainable flux control regimes featured hexose transport as a step involving high flux control.
| Original language | English |
|---|---|
| Pages (from-to) | 3894-3904 |
| Number of pages | 11 |
| Journal | European Journal of Biochemistry |
| Volume | 269 |
| Issue number | 16 |
| DOIs | |
| Publication status | Published - 31 Aug 2002 |
Keywords
- flux
- glycolysis
- metabolic control analysis
- modelling
- yeast