Schemes of flux control in a model of Saccharomyces cerevisiae glycolysis

Leighton Pritchard, Douglas B. Kell

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

We used parameter scanning to emulate changes to the limiting rate for steps in a fitted model of glucose-derepressed yeast glycolysis. Three flux-control regimes were observed, two of which were under the dominant control of hexose transport, in accordance with various experimental studies and other model predictions. A third control regime in which phosphofructokinase exerted dominant glycolytic flux control was also found, but it appeared to be physiologically unreachable by this model, and all realistically obtainable flux control regimes featured hexose transport as a step involving high flux control.

Original languageEnglish
Pages (from-to)3894-3904
Number of pages11
JournalEuropean Journal of Biochemistry
Volume269
Issue number16
DOIs
Publication statusPublished - 31 Aug 2002

Keywords

  • flux
  • glycolysis
  • metabolic control analysis
  • modelling
  • yeast

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