SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland

Sarah J Stock; Jade Carruthers; Clara Calvert; Cheryl Denny; Jack Donaghy; Anna Goulding; Lisa E M Hopcroft; Leanne Hopkins; Terry McLaughlin; Jiafeng Pan; Ting Shi; Bob Taylor; Utkarsh Agrawal; Bonnie Auyeung; Srinivasa Vittal Katikireddi; Colin McCowan; Josie Murray; Colin R Simpson; Chris Robertson; Eleftheria Vasileiou; Aziz Sheikh; Rachael Wood

doi:10.1038/s41591-021-01666-2

SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland

Sarah J Stock, Jade Carruthers, Clara Calvert, Cheryl Denny, Jack Donaghy, Anna Goulding, Lisa E M Hopcroft, Leanne Hopkins, Terry McLaughlin, Jiafeng Pan, Ting Shi, Bob Taylor, Utkarsh Agrawal, Bonnie Auyeung, Srinivasa Vittal Katikireddi, Colin McCowan, Josie Murray, Colin R Simpson, Chris Robertson, Eleftheria VasileiouAziz Sheikh, Rachael Wood

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Abstract

Population-level data on COVID-19 vaccine uptake in pregnancy and SARS-CoV-2 infection outcomes are lacking. We describe COVID-19 vaccine uptake and SARS-CoV-2 infection in pregnant women in Scotland, using whole-population data from a national, prospective cohort. Between the start of a COVID-19 vaccine program in Scotland, on 8 December 2020 and 31 October 2021, 25,917 COVID-19 vaccinations were given to 18,457 pregnant women. Vaccine coverage was substantially lower in pregnant women than in the general female population of 18-44 years; 32.3% of women giving birth in October 2021 had two doses of vaccine compared to 77.4% in all women. The extended perinatal mortality rate for women who gave birth within 28 d of a COVID-19 diagnosis was 22.6 per 1,000 births (95% CI 12.9-38.5; pandemic background rate 5.6 per 1,000 births; 452 out of 80,456; 95% CI 5.1-6.2). Overall, 77.4% (3,833 out of 4,950; 95% CI 76.2-78.6) of SARS-CoV-2 infections, 90.9% (748 out of 823; 95% CI 88.7-92.7) of SARS-CoV-2 associated with hospital admission and 98% (102 out of 104; 95% CI 92.5-99.7) of SARS-CoV-2 associated with critical care admission, as well as all baby deaths, occurred in pregnant women who were unvaccinated at the time of COVID-19 diagnosis. Addressing low vaccine uptake rates in pregnant women is imperative to protect the health of women and babies in the ongoing pandemic. [Abstract copyright: © 2022. The Author(s).]

Original language	English
Pages (from-to)	504-512
Number of pages	9
Journal	Nature Medicine
Volume	28
Issue number	3
Early online date	13 Jan 2022
DOIs	https://doi.org/10.1038/s41591-021-01666-2
Publication status	Published - 31 Mar 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Covid-19
pregnancy
pregnant women
vaccine uptake
SARS-CoV-2
Scotland
vaccination rates

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10.1038/s41591-021-01666-2Licence: CC BY 4.0

Stock-etal-NM-2021-SARS-CoV-2-infection-and-COVID-19-vaccination-rates-in-pregnant-women-in-ScotlandFinal published version, 4.35 MBLicence: CC BY 4.0

Author correction: SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland
Stock, S. J., Carruthers, J., Calvert, C., Denny, C., Donaghy, J., Goulding, A., Hopcroft, L. E. M., Hopkins, L., McLaughlin, T., Pan, J., Shi, T., Taylor, B., Agrawal, U., Auyeung, B., Katikireddi, S. V., McCowan, C., Murray, J., Simpson, C. R., Robertson, C. & Vasileiou, E. & 2 others, Sheikh, A. & Wood, R., 4 Feb 2022, In: Nature Medicine. 28, 3, 1 p.
Research output: Contribution to journal › Article › peer-review

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17 Downloads (Pure)

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Stock, S. J., Carruthers, J., Calvert, C., Denny, C., Donaghy, J., Goulding, A., Hopcroft, L. E. M., Hopkins, L., McLaughlin, T., Pan, J., Shi, T., Taylor, B., Agrawal, U., Auyeung, B., Katikireddi, S. V., McCowan, C., Murray, J., Simpson, C. R., Robertson, C., ... Wood, R. (2022). SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland. Nature Medicine, 28(3), 504-512. https://doi.org/10.1038/s41591-021-01666-2

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title = "SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland",

abstract = "Population-level data on COVID-19 vaccine uptake in pregnancy and SARS-CoV-2 infection outcomes are lacking. We describe COVID-19 vaccine uptake and SARS-CoV-2 infection in pregnant women in Scotland, using whole-population data from a national, prospective cohort. Between the start of a COVID-19 vaccine program in Scotland, on 8 December 2020 and 31 October 2021, 25,917 COVID-19 vaccinations were given to 18,457 pregnant women. Vaccine coverage was substantially lower in pregnant women than in the general female population of 18-44 years; 32.3\% of women giving birth in October 2021 had two doses of vaccine compared to 77.4\% in all women. The extended perinatal mortality rate for women who gave birth within 28 d of a COVID-19 diagnosis was 22.6 per 1,000 births (95\% CI 12.9-38.5; pandemic background rate 5.6 per 1,000 births; 452 out of 80,456; 95\% CI 5.1-6.2). Overall, 77.4\% (3,833 out of 4,950; 95\% CI 76.2-78.6) of SARS-CoV-2 infections, 90.9\% (748 out of 823; 95\% CI 88.7-92.7) of SARS-CoV-2 associated with hospital admission and 98\% (102 out of 104; 95\% CI 92.5-99.7) of SARS-CoV-2 associated with critical care admission, as well as all baby deaths, occurred in pregnant women who were unvaccinated at the time of COVID-19 diagnosis. Addressing low vaccine uptake rates in pregnant women is imperative to protect the health of women and babies in the ongoing pandemic. [Abstract copyright: {\textcopyright} 2022. The Author(s).]",

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author = "Stock, \{Sarah J\} and Jade Carruthers and Clara Calvert and Cheryl Denny and Jack Donaghy and Anna Goulding and Hopcroft, \{Lisa E M\} and Leanne Hopkins and Terry McLaughlin and Jiafeng Pan and Ting Shi and Bob Taylor and Utkarsh Agrawal and Bonnie Auyeung and Katikireddi, \{Srinivasa Vittal\} and Colin McCowan and Josie Murray and Simpson, \{Colin R\} and Chris Robertson and Eleftheria Vasileiou and Aziz Sheikh and Rachael Wood",

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Stock, SJ, Carruthers, J, Calvert, C, Denny, C, Donaghy, J, Goulding, A, Hopcroft, LEM, Hopkins, L, McLaughlin, T, Pan, J, Shi, T, Taylor, B, Agrawal, U, Auyeung, B, Katikireddi, SV, McCowan, C, Murray, J, Simpson, CR, Robertson, C, Vasileiou, E, Sheikh, A & Wood, R 2022, 'SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland', Nature Medicine, vol. 28, no. 3, pp. 504-512. https://doi.org/10.1038/s41591-021-01666-2

TY - JOUR

T1 - SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland

AU - Stock, Sarah J

AU - Carruthers, Jade

AU - Calvert, Clara

AU - Denny, Cheryl

AU - Donaghy, Jack

AU - Goulding, Anna

AU - Hopcroft, Lisa E M

AU - Hopkins, Leanne

AU - McLaughlin, Terry

AU - Pan, Jiafeng

AU - Shi, Ting

AU - Taylor, Bob

AU - Agrawal, Utkarsh

AU - Auyeung, Bonnie

AU - Katikireddi, Srinivasa Vittal

AU - McCowan, Colin

AU - Murray, Josie

AU - Simpson, Colin R

AU - Robertson, Chris

AU - Vasileiou, Eleftheria

AU - Sheikh, Aziz

AU - Wood, Rachael

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N2 - Population-level data on COVID-19 vaccine uptake in pregnancy and SARS-CoV-2 infection outcomes are lacking. We describe COVID-19 vaccine uptake and SARS-CoV-2 infection in pregnant women in Scotland, using whole-population data from a national, prospective cohort. Between the start of a COVID-19 vaccine program in Scotland, on 8 December 2020 and 31 October 2021, 25,917 COVID-19 vaccinations were given to 18,457 pregnant women. Vaccine coverage was substantially lower in pregnant women than in the general female population of 18-44 years; 32.3% of women giving birth in October 2021 had two doses of vaccine compared to 77.4% in all women. The extended perinatal mortality rate for women who gave birth within 28 d of a COVID-19 diagnosis was 22.6 per 1,000 births (95% CI 12.9-38.5; pandemic background rate 5.6 per 1,000 births; 452 out of 80,456; 95% CI 5.1-6.2). Overall, 77.4% (3,833 out of 4,950; 95% CI 76.2-78.6) of SARS-CoV-2 infections, 90.9% (748 out of 823; 95% CI 88.7-92.7) of SARS-CoV-2 associated with hospital admission and 98% (102 out of 104; 95% CI 92.5-99.7) of SARS-CoV-2 associated with critical care admission, as well as all baby deaths, occurred in pregnant women who were unvaccinated at the time of COVID-19 diagnosis. Addressing low vaccine uptake rates in pregnant women is imperative to protect the health of women and babies in the ongoing pandemic. [Abstract copyright: © 2022. The Author(s).]

AB - Population-level data on COVID-19 vaccine uptake in pregnancy and SARS-CoV-2 infection outcomes are lacking. We describe COVID-19 vaccine uptake and SARS-CoV-2 infection in pregnant women in Scotland, using whole-population data from a national, prospective cohort. Between the start of a COVID-19 vaccine program in Scotland, on 8 December 2020 and 31 October 2021, 25,917 COVID-19 vaccinations were given to 18,457 pregnant women. Vaccine coverage was substantially lower in pregnant women than in the general female population of 18-44 years; 32.3% of women giving birth in October 2021 had two doses of vaccine compared to 77.4% in all women. The extended perinatal mortality rate for women who gave birth within 28 d of a COVID-19 diagnosis was 22.6 per 1,000 births (95% CI 12.9-38.5; pandemic background rate 5.6 per 1,000 births; 452 out of 80,456; 95% CI 5.1-6.2). Overall, 77.4% (3,833 out of 4,950; 95% CI 76.2-78.6) of SARS-CoV-2 infections, 90.9% (748 out of 823; 95% CI 88.7-92.7) of SARS-CoV-2 associated with hospital admission and 98% (102 out of 104; 95% CI 92.5-99.7) of SARS-CoV-2 associated with critical care admission, as well as all baby deaths, occurred in pregnant women who were unvaccinated at the time of COVID-19 diagnosis. Addressing low vaccine uptake rates in pregnant women is imperative to protect the health of women and babies in the ongoing pandemic. [Abstract copyright: © 2022. The Author(s).]

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KW - pregnancy

KW - pregnant women

KW - vaccine uptake

KW - SARS-CoV-2

KW - Scotland

KW - vaccination rates

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DO - 10.1038/s41591-021-01666-2

M3 - Article

C2 - 35027756

SN - 1078-8956

VL - 28

SP - 504

EP - 512

JO - Nature Medicine

JF - Nature Medicine

IS - 3

ER -

SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland

Abstract

UN SDGs

Keywords

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Research output

Author correction: SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland

Cite this