Abstract
The inorganic cage compounds, dicarba-closo-dodecaboranes (carboranes), are chemical building blocks of remarkable thermal and chemical stability, with spherical geometry and exceptional hydrophobic character. We have focused on medicinal drug design using carboranes as a hydrophobic pharmacophore and have developed a potent estrogen agonist, BE120. We also have applied carboranes for structural chemistry, utilizing their specific three-dimensional character to obtain multilayer aromatic structures.
Original language | English |
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Pages (from-to) | 795-798 |
Number of pages | 3 |
Journal | Phosphorus, Sulfur, and Silicon and the Related Elements |
Volume | 179 |
Issue number | 4/5 |
DOIs | |
Publication status | Published - Apr 2004 |
Keywords
- inorganic cage compounds
- dicarba-closo-dodecaboranes
- carboranes
- chemical
- hydrophobic
- medicinal pharmacophore
- estrogen agonist
- BE120
- aromatic