The inorganic cage compounds, dicarba-closo-dodecaboranes (carboranes), are chemical building blocks of remarkable thermal and chemical stability, with spherical geometry and exceptional hydrophobic character. We have focused on medicinal drug design using carboranes as a hydrophobic pharmacophore and have developed a potent estrogen agonist, BE120. We also have applied carboranes for structural chemistry, utilizing their specific three-dimensional character to obtain multilayer aromatic structures.
|Number of pages||3|
|Journal||Phosphorus, Sulfur, and Silicon and the Related Elements|
|Publication status||Published - Apr 2004|
- inorganic cage compounds
- medicinal pharmacophore
- estrogen agonist