S-block complexes of a, α'-stabilized carbanions: Rings, chains, and 2D networks

K.W. Henderson, A.R. Kennedy, D.J. MacDougall

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The inorganic cage compounds, dicarba-closo-dodecaboranes (carboranes), are chemical building blocks of remarkable thermal and chemical stability, with spherical geometry and exceptional hydrophobic character. We have focused on medicinal drug design using carboranes as a hydrophobic pharmacophore and have developed a potent estrogen agonist, BE120. We also have applied carboranes for structural chemistry, utilizing their specific three-dimensional character to obtain multilayer aromatic structures.
LanguageEnglish
Pages795-798
Number of pages3
JournalPhosphorus, Sulfur, and Silicon and the Related Elements
Volume179
Issue number4/5
DOIs
Publication statusPublished - Apr 2004

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Drug Design
Chemical stability
Multilayers
Estrogens
Thermodynamic stability
Hot Temperature
Geometry
Pharmaceutical Preparations

Keywords

  • inorganic cage compounds
  • dicarba-closo-dodecaboranes
  • carboranes
  • chemical
  • hydrophobic
  • medicinal pharmacophore
  • estrogen agonist
  • BE120
  • aromatic

Cite this

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S-block complexes of a, α'-stabilized carbanions: Rings, chains, and 2D networks. / Henderson, K.W.; Kennedy, A.R.; MacDougall, D.J.

In: Phosphorus, Sulfur, and Silicon and the Related Elements , Vol. 179, No. 4/5, 04.2004, p. 795-798.

Research output: Contribution to journalArticle

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