Ruthenium bipyridyl complexes as photocleavable dimerizers: deactivation of DNA-binding peptides using visible light

Jesús Mosquera, Mateo I. Sánchez, M. Eugenio Vázquez, José L. Mascareñas

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We report a photolabile biselectrophilic Ru(ii) complex that can be used for homo- or heterodimerization of cysteine-containing peptides. The resulting dimers can be efficiently disassembled by long-wavelength light. As proof-of-concept, we describe the preparation of homo-and heterodimeric bZIP peptides whose DNA-binding properties can be turned off using visible light.

Original languageEnglish
Pages (from-to)10975-10978
Number of pages4
JournalChemical Communications
Volume50
Issue number75
DOIs
Publication statusPublished - 21 Aug 2014

Keywords

  • ruthenium bipyridyl complexes
  • photolabile biselectrophilic Ru(II) complex
  • visible light

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