Abstract
The global incidence, associated mortality rates and economic burden of diabetes are now such that it is considered one of the most pressing worldwide public health challenges. Considerable research is now devoted to better understanding the mechanisms underlying the onset and progression of this disease, with an ultimate aim of improving the array of available preventive and therapeutic interventions. One area of particular unmet clinical need is the significantly elevated rate of cardiomyopathy in diabetic patients, which in part contributes to cardiovascular disease being the primary cause of premature death in this population. This review will first consider the role of metabolism and more specifically the insulin sensitive glucose transporter GLUT4 in diabetic cardiac disease, before addressing how we may use exercise to intervene in order to beneficially impact key functional clinical outcomes.
| Original language | English |
|---|---|
| Article number | e11485 |
| Number of pages | 35 |
| Journal | PeerJ |
| Volume | 9 |
| DOIs | |
| Publication status | Published - 25 May 2021 |
Funding
The following grant information was disclosed by the authors: British Heart Foundation: PG/18/47/33833. PhD scholarship: FS/14/61/31284. Work in the GLS and GWG groups is supported by British Heart Foundation project grant PG/18/47/33833 (Godfrey L. Smith and Gwyn W. Gould) and PhD scholarship FS/14/61/ 31284 (to Peter R.T. Bowman). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Keywords
- cardiomyocyte
- diabetic cardiomyopathy
- exercise
- glucose
- GLUT4