Run for your life: can exercise be used to effectively target GLUT4 in diabetic cardiac disease?

Research output: Contribution to journalArticlepeer-review

Abstract

The global incidence, associated mortality rates and economic burden of diabetes are now such that it is considered one of the most pressing worldwide public health challenges. Considerable research is now devoted to better understanding the mechanisms underlying the onset and progression of this disease, with an ultimate aim of improving the array of available preventive and therapeutic interventions. One area of particular unmet clinical need is the significantly elevated rate of cardiomyopathy in diabetic patients, which in part contributes to cardiovascular disease being the primary cause of premature death in this population. This review will first consider the role of metabolism and more specifically the insulin sensitive glucose transporter GLUT4 in diabetic cardiac disease, before addressing how we may use exercise to intervene in order to beneficially impact key functional clinical outcomes.

Original languageEnglish
Article numbere11485
Number of pages35
JournalPeerJ
Volume9
DOIs
Publication statusPublished - 25 May 2021

Keywords

  • cardiomyocyte
  • diabetic cardiomyopathy
  • exercise
  • glucose
  • GLUT4

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