Roles of D1-like dopamine receptors in the nucleus accumbens and dorsolateral striatum in conditioned avoidance responses

Evellyn Claudia Wietzikoski, Suelen Lúcio Boschen, Edmar Miyoshi, Mariza Bortolanza, Lucélia Mendes Dos Santos, Michael Frank, Marcus Lira Brandão, Philip Winn, Claudio Da Cunha

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Aversively motivated learning is more poorly understood than appetitively motivated learning in many aspects, including the role of dopamine receptors in different regions of the striatum. The present study investigated the roles of the D1-like DA receptors in the nucleus accumbens (NAc) and dorsolateral striatum (DLS) on learning and performance of conditioned avoidance responses (CARs). Adult male Wistar rats received intraperitoneal (i.p.), intra-NAc, or intra-DLS injections of the D1 dopamine receptor agonist SKF 81297 or the D1 receptor antagonist SCH 23390 20 min before or immediately after a training session in the CAR task two-way active avoidance, carried out 24 h before a test session. Pre-training administration of SCH 23390, but not SKF 81297, caused a significant decrease in the number of CARs in the test, but not in the training session, when injected into the DLS, or in either session when injected into the NAc. It also caused a significant increase in the number of escape failures in the training session when injected into the NAc. Systemic administration caused a combination of these effects. Post-training administrations of these drugs caused no significant effect. The results suggest that the D1-like receptors in the NAc and DLS play important, though different, roles in learning and performance of CAR.
LanguageEnglish
Pages159-169
Number of pages11
JournalPsychopharmacology
Volume219
Issue number1
DOIs
Publication statusPublished - 2012

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Dopamine D1 Receptors
Nucleus Accumbens
Learning
Dopamine Agonists
Dopamine Receptors
Wistar Rats
Injections
Pharmaceutical Preparations

Keywords

  • dopamine receptors
  • nucleus accumbens
  • dorsolateral striatum
  • conditioned avoidance responses

Cite this

Wietzikoski, E. C., Boschen, S. L., Miyoshi, E., Bortolanza, M., Dos Santos, L. M., Frank, M., ... Da Cunha, C. (2012). Roles of D1-like dopamine receptors in the nucleus accumbens and dorsolateral striatum in conditioned avoidance responses. Psychopharmacology, 219(1), 159-169. https://doi.org/10.1007/s00213-011-2384-3
Wietzikoski, Evellyn Claudia ; Boschen, Suelen Lúcio ; Miyoshi, Edmar ; Bortolanza, Mariza ; Dos Santos, Lucélia Mendes ; Frank, Michael ; Brandão, Marcus Lira ; Winn, Philip ; Da Cunha, Claudio. / Roles of D1-like dopamine receptors in the nucleus accumbens and dorsolateral striatum in conditioned avoidance responses. In: Psychopharmacology. 2012 ; Vol. 219, No. 1. pp. 159-169.
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Wietzikoski, EC, Boschen, SL, Miyoshi, E, Bortolanza, M, Dos Santos, LM, Frank, M, Brandão, ML, Winn, P & Da Cunha, C 2012, 'Roles of D1-like dopamine receptors in the nucleus accumbens and dorsolateral striatum in conditioned avoidance responses' Psychopharmacology, vol. 219, no. 1, pp. 159-169. https://doi.org/10.1007/s00213-011-2384-3

Roles of D1-like dopamine receptors in the nucleus accumbens and dorsolateral striatum in conditioned avoidance responses. / Wietzikoski, Evellyn Claudia; Boschen, Suelen Lúcio; Miyoshi, Edmar; Bortolanza, Mariza; Dos Santos, Lucélia Mendes; Frank, Michael; Brandão, Marcus Lira; Winn, Philip; Da Cunha, Claudio.

In: Psychopharmacology, Vol. 219, No. 1, 2012, p. 159-169.

Research output: Contribution to journalArticle

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