Role of RIM1α in short-and long-term synaptic plasticity at cerebellar parallel fibres

Michael Kintscher, Christian Wozny, Friedrich W. Johenning, Dietmar Schmitz, Jörg Breustedt

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The presynaptic terminals of synaptic connections are composed of a complex network of interacting proteins that collectively ensure proper synaptic transmission and plasticity characteristics. The key components of this network are the members of the RIM protein family. Here we show that RIM1α can influence short-term plasticity at cerebellar parallel-fibre synapses. We demonstrate that the loss of a single RIM isoform, RIM1α, leads to reduced calcium influx in cerebellar granule cell terminals, decreased release probability and consequently an enhanced short-term facilitation. In contrast, we find that presynaptic long-term plasticity is fully intact in the absence of RIM1α, arguing against its necessary role in the expression of this important process. Our data argue for a universal role of RIM1α in setting release probability via interaction with voltage-dependent calcium channels at different connections instead of synapse-specific functions.

LanguageEnglish
Article number2392
Number of pages8
JournalNature Communications
Volume4
DOIs
Publication statusPublished - 3 Sep 2013

Fingerprint

Neuronal Plasticity
plastic properties
Synapses
Plasticity
Reaction injection molding
synapses
fibers
Fibers
calcium
Presynaptic Terminals
Calcium Channels
Synaptic Transmission
proteins
Protein Isoforms
Proteins
Complex networks
Calcium
electric potential
cells
interactions

Keywords

  • synaptic transmission
  • synaptic plasticity
  • RIM1a
  • neuronal networks

Cite this

Kintscher, Michael ; Wozny, Christian ; Johenning, Friedrich W. ; Schmitz, Dietmar ; Breustedt, Jörg. / Role of RIM1α in short-and long-term synaptic plasticity at cerebellar parallel fibres. In: Nature Communications. 2013 ; Vol. 4.
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Role of RIM1α in short-and long-term synaptic plasticity at cerebellar parallel fibres. / Kintscher, Michael; Wozny, Christian; Johenning, Friedrich W.; Schmitz, Dietmar; Breustedt, Jörg.

In: Nature Communications, Vol. 4, 2392, 03.09.2013.

Research output: Contribution to journalArticle

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