Role of IL-33 and ST2 signalling pathway in multiple sclerosis: expression by oligodendrocytes and inhibition of myelination in central nervous system

Debbie Allan, Karen J Fairlie-Clarke, Christina Elliott, Cornelia Schuh, Susan C Barnett, Hans Lassmann, Christopher Linnington, Hui-Rong Jiang

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Recent research findings have provided convincing evidence indicating a role for Interleukin-33 (IL-33) signalling pathway in a number of central nervous system (CNS) diseases including multiple sclerosis (MS) and Alzheimer's disease. However, the exact function of IL-33 molecule within the CNS under normal and pathological conditions is currently unknown. In this study, we have mapped cellular expression of IL-33 and its receptor ST2 by immunohistochemistry in the brain tissues of MS patients and appropriate controls; and investigated the functional significance of these findings in vitro using a myelinating culture system. Our results demonstrate that IL-33 is expressed by neurons, astrocytes and microglia as well as oligodendrocytes, while ST2 is expressed in the lesions by oligodendrocytes and within and around axons. Furthermore, the expression levels and patterns of IL-33 and ST2 in the lesions of acute and chronic MS patient brain samples are enhanced compared with the healthy brain tissues. Finally, our data using rat myelinating co-cultures suggest that IL-33 may play an important role in MS development by inhibiting CNS myelination.

LanguageEnglish
Article number75
Number of pages10
JournalActa neuropathologica communications
Volume4
Issue number1
DOIs
Publication statusPublished - 26 Jul 2016

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Oligodendroglia
Multiple Sclerosis
Central Nervous System
Brain
Central Nervous System Diseases
Microglia
Coculture Techniques
Astrocytes
Axons
Alzheimer Disease
Immunohistochemistry
Interleukin-33
Inhibition (Psychology)
Neurons
Research

Keywords

  • IL-33
  • ST2
  • multiple sclerosis
  • oligedendrocyte
  • myelination

Cite this

Allan, Debbie ; Fairlie-Clarke, Karen J ; Elliott, Christina ; Schuh, Cornelia ; Barnett, Susan C ; Lassmann, Hans ; Linnington, Christopher ; Jiang, Hui-Rong. / Role of IL-33 and ST2 signalling pathway in multiple sclerosis : expression by oligodendrocytes and inhibition of myelination in central nervous system. In: Acta neuropathologica communications. 2016 ; Vol. 4, No. 1.
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Role of IL-33 and ST2 signalling pathway in multiple sclerosis : expression by oligodendrocytes and inhibition of myelination in central nervous system. / Allan, Debbie; Fairlie-Clarke, Karen J; Elliott, Christina; Schuh, Cornelia; Barnett, Susan C; Lassmann, Hans; Linnington, Christopher; Jiang, Hui-Rong.

In: Acta neuropathologica communications, Vol. 4, No. 1, 75, 26.07.2016.

Research output: Contribution to journalArticle

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