Role of five synthetic reaction conditions on the stable isotopic composition of 3,4-methylenedioxymethamphetamine

Hilary A.S. Buchanan, Niamh Nic Daeid, William J. Kerr, James F. Carter, Jenny C. Hill

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The identification of links between seizures of illicit 3,4- methylenedioxymethamphetamine (MDMA or 'ecstasy') has been a global target of law enforcement agencies in recent years. Previous work has shown that, when the reaction conditions are carefully repeated from batch to batch, stable isotope ratios allow the discrimination of MDMA· HCl batches according to synthetic route used for manufacture. In this study, the effects of altering five reaction conditions relating to the Pt/H2 reductive amination synthesis were, for the first time, systematically investigated using a two level, five factor factorial design. Results indicate that the δ2H values of MDMA· HCl are affected by the length of imine stir time, and the δ15N values are affected by the degree of excess methylamine employed. Furthermore, the δ13C and δ18O values have been shown to be affected by the efficiency of the reaction, despite the similarity in carbon and oxygen composition of the starting material and product molecules. In addition to being of theoreticalimportance in this field of analytical science overall, this work is essential in order to more fully contextualize the interpretation of IRMS data which may be used as potential forensic evidence.
LanguageEnglish
Pages5484-5489
Number of pages6
JournalAnalytical Chemistry
Volume82
Issue number13
Early online date1 Jun 2010
DOIs
Publication statusPublished - 1 Jul 2010

Fingerprint

N-Methyl-3,4-methylenedioxyamphetamine
Chemical analysis
Imines
Law enforcement
Isotopes
Carbon
Oxygen
Molecules

Keywords

  • isotopic composition
  • analytical chemistry

Cite this

Buchanan, Hilary A.S. ; Daeid, Niamh Nic ; Kerr, William J. ; Carter, James F. ; Hill, Jenny C. / Role of five synthetic reaction conditions on the stable isotopic composition of 3,4-methylenedioxymethamphetamine. In: Analytical Chemistry. 2010 ; Vol. 82, No. 13. pp. 5484-5489.
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Role of five synthetic reaction conditions on the stable isotopic composition of 3,4-methylenedioxymethamphetamine. / Buchanan, Hilary A.S.; Daeid, Niamh Nic; Kerr, William J.; Carter, James F.; Hill, Jenny C.

In: Analytical Chemistry, Vol. 82, No. 13, 01.07.2010, p. 5484-5489.

Research output: Contribution to journalArticle

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