Background: Recent researches pointed to executive dysfunction as a potential early predictor of the progression Mild Cognitive Impairment (MCI) dementia in clinical syndrome (ACS). Such cognitive impairments account for functional impairments in instrumental activities of daily living (IADL). Objective: The present study analyse the contributions of executive functions to predict MCI dementia progression in ACS. Methods: We assessed 145 participants, 51 cognitively unimpaired and 94 MCI. The latter were divided using the traditional, memory-based MCI classification (single domain amnestic, multidomain amnestic and non-amnestic). Eight tests assessing executive functions were administered at baseline and at 1-year follow-up, together with cognitive screening tools and IADL measures. MCI patients were reclassified based on the outcomes from a K-mean cluster analysis which identified three groups. A simple lineal regression model was used to examine whether the classification based on executive functioning could more accurately predict progression to dementia a year later. Results: Clusters based on executive function deficits explained a significant proportion of the variance linked to MCI dementia conversion, even after controlling for the severity of MCI at baseline (F(1, 68) = 116.25, p=0.000, R2=0.63). Classical memory-based MCI classification failed to predict such a conversion (F(1, 68) = 5.09, p=0.955, R2=0.07). Switching, categories generation and planning were the executive functions that best distinguished between MCI converters and stable. Conclusion: MCI with a dysexecutive phenotype significantly predicts conversion to dementia in ACS a year later. Switching abilities and verbal fluency (categories) must be evaluated in MCI patients to assess risk of future dementia.
|Number of pages||37|
|Journal||Journal of Alzheimer's Disease|
|Publication status||Accepted/In press - 17 Jun 2020|
- activities of daily living
- alzheimer disease
- cognitive dysfunction
- executive function
- longitudinal studies
Junquera Fernández, A., García-Zamora, E., Olazarán-Rodriguez, J., Parra Rodriguez, M. A., & Fernández Guinea, S. (Accepted/In press). Role of executive functions in the conversion from mild cognitive impairment to dementia. Journal of Alzheimer's Disease.