Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada

W. H. Lin; Rainer Ebel; Ruangelie Edrada-Ebel; Victor Wray; Manfred Nimtz; W Sumaryono; Peter Proksch

doi:10.1021/np0102354

Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada

W. H. Lin, Rainer Ebel, Ruangelie Edrada-Ebel, Victor Wray, Manfred Nimtz, W Sumaryono, Peter Proksch

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article

38 Citations (Scopus)

Abstract

A phytochemical analysis of the leaves of Aglaia dasyclada collected in Yunnan Province (People's Republic of China) yielded five cyclopentabenzofurans (1-5) of the rocaglamide family that are common secondary metabolites of Aglaia species as well as four biogenetically related compounds of the aglain (7), aglaforbesin (8) and forbaglin (9, 10) types. In addition, the cinnamic acid amide dasyclamide (6), which is a putative biogenetic precursor of these compounds (7-10), was isolated. The structures of the new compounds (6-10) were assigned unambiguously from the combined use of 1D and 2D NMR spectroscopy and mass spectrometry.

Original language	English
Pages (from-to)	1216-1220
Number of pages	5
Journal	Journal of Natural Products
Volume	64
Issue number	9
DOIs	https://doi.org/10.1021/np0102354
Publication status	Published - Sept 2001

Keywords

animals
benzofurans
China
chromatography, high pressure liquid
thin layer chromatography
circular dichroism
dose-response relationship, drug
feeding behavior
glycosides
insecticides
larva
magnetic resonance spectroscopy
mass spectrometry
meliaceae
molecular structure
plant leaves
plants, Medicinal
putrescine
spodoptera
stereoisomerisms

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10.1021/np0102354

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title = "Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada",

abstract = "A phytochemical analysis of the leaves of Aglaia dasyclada collected in Yunnan Province (People's Republic of China) yielded five cyclopentabenzofurans (1-5) of the rocaglamide family that are common secondary metabolites of Aglaia species as well as four biogenetically related compounds of the aglain (7), aglaforbesin (8) and forbaglin (9, 10) types. In addition, the cinnamic acid amide dasyclamide (6), which is a putative biogenetic precursor of these compounds (7-10), was isolated. The structures of the new compounds (6-10) were assigned unambiguously from the combined use of 1D and 2D NMR spectroscopy and mass spectrometry.",

keywords = "animals, benzofurans, China, chromatography, high pressure liquid, thin layer chromatography, circular dichroism, dose-response relationship, drug, feeding behavior, glycosides, insecticides, larva, magnetic resonance spectroscopy, mass spectrometry, meliaceae, molecular structure, plant leaves, plants, Medicinal, putrescine, spodoptera, stereoisomerisms",

author = "Lin, {W. H.} and Rainer Ebel and Ruangelie Edrada-Ebel and Victor Wray and Manfred Nimtz and W Sumaryono and Peter Proksch",

year = "2001",

month = sep,

doi = "10.1021/np0102354",

language = "English",

volume = "64",

pages = "1216--1220",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada

AU - Lin, W. H.

AU - Ebel, Rainer

AU - Edrada-Ebel, Ruangelie

AU - Wray, Victor

AU - Nimtz, Manfred

AU - Sumaryono, W

AU - Proksch, Peter

PY - 2001/9

Y1 - 2001/9

N2 - A phytochemical analysis of the leaves of Aglaia dasyclada collected in Yunnan Province (People's Republic of China) yielded five cyclopentabenzofurans (1-5) of the rocaglamide family that are common secondary metabolites of Aglaia species as well as four biogenetically related compounds of the aglain (7), aglaforbesin (8) and forbaglin (9, 10) types. In addition, the cinnamic acid amide dasyclamide (6), which is a putative biogenetic precursor of these compounds (7-10), was isolated. The structures of the new compounds (6-10) were assigned unambiguously from the combined use of 1D and 2D NMR spectroscopy and mass spectrometry.

AB - A phytochemical analysis of the leaves of Aglaia dasyclada collected in Yunnan Province (People's Republic of China) yielded five cyclopentabenzofurans (1-5) of the rocaglamide family that are common secondary metabolites of Aglaia species as well as four biogenetically related compounds of the aglain (7), aglaforbesin (8) and forbaglin (9, 10) types. In addition, the cinnamic acid amide dasyclamide (6), which is a putative biogenetic precursor of these compounds (7-10), was isolated. The structures of the new compounds (6-10) were assigned unambiguously from the combined use of 1D and 2D NMR spectroscopy and mass spectrometry.

KW - animals

KW - benzofurans

KW - China

KW - chromatography, high pressure liquid

KW - thin layer chromatography

KW - circular dichroism

KW - dose-response relationship, drug

KW - feeding behavior

KW - glycosides

KW - insecticides

KW - larva

KW - magnetic resonance spectroscopy

KW - mass spectrometry

KW - meliaceae

KW - molecular structure

KW - plant leaves

KW - plants, Medicinal

KW - putrescine

KW - spodoptera

KW - stereoisomerisms

U2 - 10.1021/np0102354

DO - 10.1021/np0102354

M3 - Article

C2 - 11575959

SN - 0163-3864

VL - 64

SP - 1216

EP - 1220

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 9

ER -

Rocaglamides, glycosides, and putrescine bisamides from Aglaia dasyclada

Abstract

Keywords

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