Abstract
MRI of fluids containing lipid coated microbubbles has been shown to be an effective tool for measuring the local fluid pressure. However, the intrinsically buoyant nature of these microbubbles precludes lengthy measurements due to their vertical migration under gravity and pressure-induced coalescence. A novel preparation is presented which is shown to minimize both these effects for at least 25 min. By using a 2% polysaccharide gel base with a small concentration of glycerol and 1,2-distearoyl-sn-glycero-3-phosphocholine coated gas microbubbles, MR measurements are made for pressures between 0.95 and 1.44 bar. The signal drifts due to migration and amalgamation are shown to be minimized for such an experiment whilst yielding very high NMR sensitivities up to 38% signal change per bar.
| Language | English |
|---|---|
| Pages | 159-167 |
| Number of pages | 9 |
| Journal | Journal of Magnetic Resonance |
| Volume | 193 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 31 Aug 2008 |
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Keywords
- gels
- computer assisted image interpretation
- magnetic resonance imaging
- manometry
- microbubbles
- polysaccharides
- pressure
- reproducibility of results
- sensitivity and specificity
Cite this
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Robust spatially resolved pressure measurements using MRI with novel buoyant advection-free preparations of stable microbubbles in polysaccharide gels. / Morris, Robert H; Bencsik, Martin; Nestle, Nikolaus; Galvosas, Petrik; Fairhurst, David; Vangala, Anil; Perrie, Yvonne; McHale, Glen.
In: Journal of Magnetic Resonance, Vol. 193, No. 2, 31.08.2008, p. 159-167.Research output: Contribution to journal › Article
TY - JOUR
T1 - Robust spatially resolved pressure measurements using MRI with novel buoyant advection-free preparations of stable microbubbles in polysaccharide gels
AU - Morris, Robert H
AU - Bencsik, Martin
AU - Nestle, Nikolaus
AU - Galvosas, Petrik
AU - Fairhurst, David
AU - Vangala, Anil
AU - Perrie, Yvonne
AU - McHale, Glen
PY - 2008/8/31
Y1 - 2008/8/31
N2 - MRI of fluids containing lipid coated microbubbles has been shown to be an effective tool for measuring the local fluid pressure. However, the intrinsically buoyant nature of these microbubbles precludes lengthy measurements due to their vertical migration under gravity and pressure-induced coalescence. A novel preparation is presented which is shown to minimize both these effects for at least 25 min. By using a 2% polysaccharide gel base with a small concentration of glycerol and 1,2-distearoyl-sn-glycero-3-phosphocholine coated gas microbubbles, MR measurements are made for pressures between 0.95 and 1.44 bar. The signal drifts due to migration and amalgamation are shown to be minimized for such an experiment whilst yielding very high NMR sensitivities up to 38% signal change per bar.
AB - MRI of fluids containing lipid coated microbubbles has been shown to be an effective tool for measuring the local fluid pressure. However, the intrinsically buoyant nature of these microbubbles precludes lengthy measurements due to their vertical migration under gravity and pressure-induced coalescence. A novel preparation is presented which is shown to minimize both these effects for at least 25 min. By using a 2% polysaccharide gel base with a small concentration of glycerol and 1,2-distearoyl-sn-glycero-3-phosphocholine coated gas microbubbles, MR measurements are made for pressures between 0.95 and 1.44 bar. The signal drifts due to migration and amalgamation are shown to be minimized for such an experiment whilst yielding very high NMR sensitivities up to 38% signal change per bar.
KW - gels
KW - computer assisted image interpretation
KW - magnetic resonance imaging
KW - manometry
KW - microbubbles
KW - polysaccharides
KW - pressure
KW - reproducibility of results
KW - sensitivity and specificity
UR - http://www.sciencedirect.com/science/article/pii/S1090780708001195
U2 - 10.1016/j.jmr.2008.04.025
DO - 10.1016/j.jmr.2008.04.025
M3 - Article
VL - 193
SP - 159
EP - 167
JO - Journal of Magnetic Resonance
T2 - Journal of Magnetic Resonance
JF - Journal of Magnetic Resonance
SN - 1090-7807
IS - 2
ER -