Robotic-assisted 3D bio-printing for repairing bone and cartilage defects through a minimally invasive approach

Julius Lipskas; Kamal Deep; Wei Yao

doi:10.1038/s41598-019-38972-2

Robotic-assisted 3D bio-printing for repairing bone and cartilage defects through a minimally invasive approach

Julius Lipskas, Kamal Deep, Wei Yao

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

24 Downloads (Pure)

Abstract

There is an unmet need for new techniques and methods of healing critical size tissue defects, by further reduction of invasiveness in implant, cell and tissue-based surgery. This paper presents the development of a new regenerative medicine that combines 3D bio-printing and robotic-assisted minimally invasive surgery techniques to meet this need.

We investigated the feasibility of Remote Centre of Motion (RCM) and viscous material extrusion 3D printing. A hypothetical, intra-articular, regenerative medicine-based treatment technique for focal cartilage defects of the knee was used as a potential example of the application of 3D printing in vivo.

The results of this study suggest, that RCM mechanism is feasible with viscous material extrusion 3D printing processes, without a major trade-off in imprint quality.

The achieved printing accuracy at an average dimensional error of 0.06±0.14mm in this new modality of 3D printing is comparable to those described in literature for other types of bioprinting.

Robotic assisted 3D bio-printing demonstrated here is a viable option for focal cartilage defect restoration.

Original language	English
Article number	3746
Number of pages	9
Journal	Scientific Reports
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41598-019-38972-2
Publication status	Published - 6 Mar 2019

Keywords

3D bioprinting
cartilage defects
focal cartilage
Remote Centre of Motion (RCM)
printing accuracy

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10.1038/s41598-019-38972-2Licence: CC BY 4.0

Lipskas-etal-SR-2019-Robotic-assisted-3D-bio-printing-for-repairing-bone-and-cartilageFinal published version, 1.98 MBLicence: CC BY 4.0

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Wei Yao
- w.yao@strath.ac.uk
- Biomedical Engineering - Senior Lecturer
Person: Academic

1 Finished

Medical Devices Doctoral Training Centre Renewal
Connolly, P.
EPSRC (Engineering and Physical Sciences Research Council)
1/10/08 → 31/03/18
Project: Research - Studentship

Remote centre of motion printing experiment data
Lipskas, J. (Creator), Yao, W. (Contributor) & Deep, K. (Contributor), University of Strathclyde, 8 Feb 2019
DOI: 10.15129/261432c4-ad25-47e4-a5fa-a3420e35a76c
Dataset

Cite this

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title = "Robotic-assisted 3D bio-printing for repairing bone and cartilage defects through a minimally invasive approach",

abstract = "There is an unmet need for new techniques and methods of healing critical size tissue defects, by further reduction of invasiveness in implant, cell and tissue-based surgery. This paper presents the development of a new regenerative medicine that combines 3D bio-printing and robotic-assisted minimally invasive surgery techniques to meet this need.We investigated the feasibility of Remote Centre of Motion (RCM) and viscous material extrusion 3D printing. A hypothetical, intra-articular, regenerative medicine-based treatment technique for focal cartilage defects of the knee was used as a potential example of the application of 3D printing in vivo.The results of this study suggest, that RCM mechanism is feasible with viscous material extrusion 3D printing processes, without a major trade-off in imprint quality.The achieved printing accuracy at an average dimensional error of 0.06±0.14mm in this new modality of 3D printing is comparable to those described in literature for other types of bioprinting.Robotic assisted 3D bio-printing demonstrated here is a viable option for focal cartilage defect restoration.",

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author = "Julius Lipskas and Kamal Deep and Wei Yao",

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N2 - There is an unmet need for new techniques and methods of healing critical size tissue defects, by further reduction of invasiveness in implant, cell and tissue-based surgery. This paper presents the development of a new regenerative medicine that combines 3D bio-printing and robotic-assisted minimally invasive surgery techniques to meet this need.We investigated the feasibility of Remote Centre of Motion (RCM) and viscous material extrusion 3D printing. A hypothetical, intra-articular, regenerative medicine-based treatment technique for focal cartilage defects of the knee was used as a potential example of the application of 3D printing in vivo.The results of this study suggest, that RCM mechanism is feasible with viscous material extrusion 3D printing processes, without a major trade-off in imprint quality.The achieved printing accuracy at an average dimensional error of 0.06±0.14mm in this new modality of 3D printing is comparable to those described in literature for other types of bioprinting.Robotic assisted 3D bio-printing demonstrated here is a viable option for focal cartilage defect restoration.

AB - There is an unmet need for new techniques and methods of healing critical size tissue defects, by further reduction of invasiveness in implant, cell and tissue-based surgery. This paper presents the development of a new regenerative medicine that combines 3D bio-printing and robotic-assisted minimally invasive surgery techniques to meet this need.We investigated the feasibility of Remote Centre of Motion (RCM) and viscous material extrusion 3D printing. A hypothetical, intra-articular, regenerative medicine-based treatment technique for focal cartilage defects of the knee was used as a potential example of the application of 3D printing in vivo.The results of this study suggest, that RCM mechanism is feasible with viscous material extrusion 3D printing processes, without a major trade-off in imprint quality.The achieved printing accuracy at an average dimensional error of 0.06±0.14mm in this new modality of 3D printing is comparable to those described in literature for other types of bioprinting.Robotic assisted 3D bio-printing demonstrated here is a viable option for focal cartilage defect restoration.

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Robotic-assisted 3D bio-printing for repairing bone and cartilage defects through a minimally invasive approach

Abstract

Keywords

Access to Document

Wei Yao

Medical Devices Doctoral Training Centre Renewal

Remote centre of motion printing experiment data

Cite this