Robotic-assisted 3D bio-printing for repairing bone and cartilage defects through a minimally invasive approach

Julius Lipskas, Kamal Deep, Wei Yao

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7 Citations (Scopus)
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Abstract

There is an unmet need for new techniques and methods of healing critical size tissue defects, by further reduction of invasiveness in implant, cell and tissue-based surgery. This paper presents the development of a new regenerative medicine that combines 3D bio-printing and robotic-assisted minimally invasive surgery techniques to meet this need.

We investigated the feasibility of Remote Centre of Motion (RCM) and viscous material extrusion 3D printing. A hypothetical, intra-articular, regenerative medicine-based treatment technique for focal cartilage defects of the knee was used as a potential example of the application of 3D printing in vivo.

The results of this study suggest, that RCM mechanism is feasible with viscous material extrusion 3D printing processes, without a major trade-off in imprint quality.

The achieved printing accuracy at an average dimensional error of 0.06±0.14mm in this new modality of 3D printing is comparable to those described in literature for other types of bioprinting.

Robotic assisted 3D bio-printing demonstrated here is a viable option for focal cartilage defect restoration.
Original languageEnglish
Article number3746
Number of pages9
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - 6 Mar 2019

Keywords

  • 3D bioprinting
  • cartilage defects
  • focal cartilage
  • Remote Centre of Motion (RCM)
  • printing accuracy

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