Risk of bias in reports of in vivo research: a focus for improvement

Malcolm R. Macleod, Aaron Lawson McLean, Aikaterini Kyriakopoulou, Stylianos Serghiou, Arno de Wilde, Nicki Sherratt, Theo Hirst, Rachel Hemblade, Zsanett Bahor, Cristina Nunes-Fonseca, Aparna Potluru, Andrew Thomson, Julija Baginskitae, Kieren Egan, Hanna Vesterinen, Gillian L. Currie, Leonid Churilov, David W. Howells, Emily S. Sena

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

The reliability of experimental findings depends on the rigour of experimental design. Here we show limited reporting of measures to reduce the risk of bias in a random sample of life sciences publications, significantly lower reporting of randomisation in work published in journals of high impact, and very limited reporting of measures to reduce the risk of bias in publications from leading United Kingdom institutions. Ascertainment of differences between institutions might serve both as a measure of research quality and as a tool for institutional efforts to improve research quality.

LanguageEnglish
Article numbere1002273
Number of pages12
JournalPLOS Biology
Volume13
Issue number10
DOIs
Publication statusPublished - 13 Oct 2015

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Publication Bias
Biological Science Disciplines
Random Allocation
Research
Design of experiments
United Kingdom
Publications
Research Design
experimental design
sampling

Keywords

  • bias
  • research
  • in vivo
  • experimental design

Cite this

Macleod, M. R., Lawson McLean, A., Kyriakopoulou, A., Serghiou, S., de Wilde, A., Sherratt, N., ... Sena, E. S. (2015). Risk of bias in reports of in vivo research: a focus for improvement. PLOS Biology, 13(10), [e1002273]. https://doi.org/10.1371/journal.pbio.1002273
Macleod, Malcolm R. ; Lawson McLean, Aaron ; Kyriakopoulou, Aikaterini ; Serghiou, Stylianos ; de Wilde, Arno ; Sherratt, Nicki ; Hirst, Theo ; Hemblade, Rachel ; Bahor, Zsanett ; Nunes-Fonseca, Cristina ; Potluru, Aparna ; Thomson, Andrew ; Baginskitae, Julija ; Egan, Kieren ; Vesterinen, Hanna ; Currie, Gillian L. ; Churilov, Leonid ; Howells, David W. ; Sena, Emily S. / Risk of bias in reports of in vivo research : a focus for improvement. In: PLOS Biology. 2015 ; Vol. 13, No. 10.
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Macleod, MR, Lawson McLean, A, Kyriakopoulou, A, Serghiou, S, de Wilde, A, Sherratt, N, Hirst, T, Hemblade, R, Bahor, Z, Nunes-Fonseca, C, Potluru, A, Thomson, A, Baginskitae, J, Egan, K, Vesterinen, H, Currie, GL, Churilov, L, Howells, DW & Sena, ES 2015, 'Risk of bias in reports of in vivo research: a focus for improvement' PLOS Biology, vol. 13, no. 10, e1002273. https://doi.org/10.1371/journal.pbio.1002273

Risk of bias in reports of in vivo research : a focus for improvement. / Macleod, Malcolm R.; Lawson McLean, Aaron; Kyriakopoulou, Aikaterini; Serghiou, Stylianos; de Wilde, Arno; Sherratt, Nicki; Hirst, Theo; Hemblade, Rachel; Bahor, Zsanett; Nunes-Fonseca, Cristina; Potluru, Aparna; Thomson, Andrew; Baginskitae, Julija; Egan, Kieren; Vesterinen, Hanna; Currie, Gillian L.; Churilov, Leonid; Howells, David W.; Sena, Emily S.

In: PLOS Biology, Vol. 13, No. 10, e1002273, 13.10.2015.

Research output: Contribution to journalArticle

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AU - Sherratt, Nicki

AU - Hirst, Theo

AU - Hemblade, Rachel

AU - Bahor, Zsanett

AU - Nunes-Fonseca, Cristina

AU - Potluru, Aparna

AU - Thomson, Andrew

AU - Baginskitae, Julija

AU - Egan, Kieren

AU - Vesterinen, Hanna

AU - Currie, Gillian L.

AU - Churilov, Leonid

AU - Howells, David W.

AU - Sena, Emily S.

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Macleod MR, Lawson McLean A, Kyriakopoulou A, Serghiou S, de Wilde A, Sherratt N et al. Risk of bias in reports of in vivo research: a focus for improvement. PLOS Biology. 2015 Oct 13;13(10). e1002273. https://doi.org/10.1371/journal.pbio.1002273