Rising to the challenge

applying biofabrication approaches for better drug and chemical product development

Anthony M Holmes, Alex Charlton, Brian Derby, Lorna Ewart, Andrew Scott, Wenmiao Shu

Research output: Contribution to journalArticle

7 Citations (Scopus)
37 Downloads (Pure)

Abstract

Many industrial sectors, from pharmaceuticals to consumer products, are required to provide data on their products to demonstrate their efficacy and that they are safe for patients, consumers and the environment. This period of testing typically requires the use of animal models, the validity of which has been called into question due to the high rates of attrition across many industries. There is increasing recognition of the limitations of animal models and demands for safety and efficacy testing paradigms which embrace the latest technological advances and knowledge of human biology. This perspective article highlights the potential for biofabrication approaches (encompassing bioprinting and bioassembly strategies) to meet these needs and provides case studies from three different industry sectors to demonstrate the potential for new markets in the bioprinting community. We also present a series of recommendations to create a thriving bioprinting environment. One that operates at the forefront of science, technology and innovation to deliver improved decision-making tools for the more rapid development of medicines, agrichemicals, chemicals and consumer products, and which may reduce our reliance on animals.

Original languageEnglish
Article number033001
Number of pages8
JournalBiofabrication
Volume9
Issue number3
DOIs
Publication statusPublished - 19 Jul 2017

Fingerprint

Bioprinting
Product development
Animals
Consumer products
Industry
Animal Models
Pharmaceutical Preparations
Agrochemicals
Testing
Drug products
Medicine
Decision Making
Innovation
Decision making
Technology
Safety

Keywords

  • biofabrication
  • animal research
  • 3Rs
  • drug development
  • chemicals
  • efficacy testing
  • toxicity testing

Cite this

Holmes, Anthony M ; Charlton, Alex ; Derby, Brian ; Ewart, Lorna ; Scott, Andrew ; Shu, Wenmiao. / Rising to the challenge : applying biofabrication approaches for better drug and chemical product development. In: Biofabrication. 2017 ; Vol. 9, No. 3.
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Rising to the challenge : applying biofabrication approaches for better drug and chemical product development. / Holmes, Anthony M; Charlton, Alex; Derby, Brian; Ewart, Lorna; Scott, Andrew; Shu, Wenmiao.

In: Biofabrication, Vol. 9, No. 3, 033001, 19.07.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Rising to the challenge

T2 - applying biofabrication approaches for better drug and chemical product development

AU - Holmes, Anthony M

AU - Charlton, Alex

AU - Derby, Brian

AU - Ewart, Lorna

AU - Scott, Andrew

AU - Shu, Wenmiao

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KW - biofabrication

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