Rhythmic auditory cortex activity at multiple timescales shapes stimulus–response gain and background firing

Christoph Kayser, Caroline Wilson, Houman Safaai, Shuzo Sakata, Stefano Panzeri

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The phase of low-frequency network activity in the auditory cortex captures changes in neural excitability, entrains to the temporal structure of natural sounds, and correlates with the perceptual performance in acoustic tasks. Although these observations suggest a causal link between network rhythms and perception, it remains unknown how precisely they affect the processes by which neural populations encode sounds. We addressed this question by analyzing neural responses in the auditory cortex of anesthetized rats using stimulus–response models. These models included a parametric dependence on the phase of local field potential rhythms in both stimulus-unrelated background activity and the stimulus–response transfer function. We found that phase-dependent models better reproduced the observed responses than static models, during both stimulation with a series of natural sounds and epochs of silence. This was attributable to two factors: (1) phase-dependent variations in background firing (most prominent for delta; 1–4 Hz); and (2) modulations of response gain that rhythmically amplify and attenuate the responses at specific phases of the rhythm (prominent for frequencies between 2 and 12 Hz). These results provide a quantitative characterization of how slow auditory cortical rhythms shape sound encoding and suggest a differential contribution of network activity at different timescales. In addition, they highlight a putative mechanism that may implement the selective amplification of appropriately timed sound tokens relative to the phase of rhythmic auditory cortex activity.
LanguageEnglish
Pages7750-7762
Number of pages13
JournalJournal of Neuroscience
Volume35
Issue number20
DOIs
Publication statusPublished - 20 May 2015

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Auditory Cortex
Acoustics
Population

Keywords

  • delta rhythm
  • information coding
  • LNP models
  • network state
  • neural coding
  • receptive fields

Cite this

Kayser, Christoph ; Wilson, Caroline ; Safaai, Houman ; Sakata, Shuzo ; Panzeri, Stefano. / Rhythmic auditory cortex activity at multiple timescales shapes stimulus–response gain and background firing. In: Journal of Neuroscience. 2015 ; Vol. 35, No. 20. pp. 7750-7762.
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Rhythmic auditory cortex activity at multiple timescales shapes stimulus–response gain and background firing. / Kayser, Christoph; Wilson, Caroline; Safaai, Houman; Sakata, Shuzo; Panzeri, Stefano.

In: Journal of Neuroscience, Vol. 35, No. 20, 20.05.2015, p. 7750-7762.

Research output: Contribution to journalArticle

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