Revolutionizing prokaryotic systematics through next-generation sequencing

Vartul Sangal, Leena Nieminen, Nicholas P. Tucker, Paul A. Hoskisson

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Citations (Scopus)


Next-generation sequencing has revolutionized modern research in all life sciences. It has been applied in studying evolution, global transmission and local adaptation of pathogens, microbial ecology, genetics and physiology. In this chapter, we have provided a brief summary of recent advances in sequencing technologies and easy to use bioinformatic tools to analyse sequence data, with a focus on prokaryotic biology. We have emphasized the importance of routinely applying whole genome sequencing in prokaryotic systematics, evolution, genotyping and functional characterization.

Original languageEnglish
Title of host publicationNew Approaches to Prokaryotic Systematics
EditorsMichael Goodfellow, Iain Sutcliffe, Jongsik Chun
Number of pages27
Publication statusPublished - 28 Aug 2014

Publication series

NameMethods in Microbiology


  • bioinformatic tools
  • comparative genomics
  • de novo assembly
  • genome annotation
  • mapping
  • next-generation sequencing
  • phylogenetic analyses
  • prokaryotic systematics


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