Reversible supramolecular assembly at specific DNA Sites: nickel-promoted bivalent DNA binding with designed peptide and bipyridyl-bis(benzamidine) components

Mateo I. Sánchez; Jesús Mosquera; M. Eugenio Vázquez; José L. Mascareñas

doi:10.1002/anie.201405726

Reversible supramolecular assembly at specific DNA Sites: nickel-promoted bivalent DNA binding with designed peptide and bipyridyl-bis(benzamidine) components

Mateo I. Sánchez, Jesús Mosquera, M. Eugenio Vázquez^*, José L. Mascareñas

^*Corresponding author for this work

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

At specific DNA sites, nickel(II) salts promote the assembly of designed components, namely a bis(histidine)-modified peptide that is derived from a bZIP transcription factor and a bis(benzamidine) unit that is equipped with a bipyridine. This programmed supramolecular system with emergent properties reproduces some key characteristics of naturally occurring DNA-binding proteins, such as bivalence, selectivity, responsiveness to external agents, and reversibility.

Original language	English
Pages (from-to)	9917-9921
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	53
Issue number	37
DOIs	https://doi.org/10.1002/anie.201405726
Publication status	Published - 8 Sept 2014

Keywords

DNA recognition
minor-groove binders
peptides
self-assembly
supramolecular chemistry

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10.1002/anie.201405726

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title = "Reversible supramolecular assembly at specific DNA Sites: nickel-promoted bivalent DNA binding with designed peptide and bipyridyl-bis(benzamidine) components",

abstract = "At specific DNA sites, nickel(II) salts promote the assembly of designed components, namely a bis(histidine)-modified peptide that is derived from a bZIP transcription factor and a bis(benzamidine) unit that is equipped with a bipyridine. This programmed supramolecular system with emergent properties reproduces some key characteristics of naturally occurring DNA-binding proteins, such as bivalence, selectivity, responsiveness to external agents, and reversibility.",

keywords = "DNA recognition, minor-groove binders, peptides, self-assembly, supramolecular chemistry",

author = "S{\'a}nchez, \{Mateo I.\} and Jes{\'u}s Mosquera and V{\'a}zquez, \{M. Eugenio\} and Mascare{\~n}as, \{Jos{\'e} L.\}",

year = "2014",

month = sep,

day = "8",

doi = "10.1002/anie.201405726",

language = "English",

volume = "53",

pages = "9917--9921",

journal = "Angewandte Chemie - International Edition",

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publisher = "John Wiley and Sons Ltd",

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Reversible supramolecular assembly at specific DNA Sites: nickel-promoted bivalent DNA binding with designed peptide and bipyridyl-bis(benzamidine) components. / Sánchez, Mateo I.; Mosquera, Jesús; Vázquez, M. Eugenio et al.
In: Angewandte Chemie - International Edition, Vol. 53, No. 37, 08.09.2014, p. 9917-9921.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Reversible supramolecular assembly at specific DNA Sites

T2 - nickel-promoted bivalent DNA binding with designed peptide and bipyridyl-bis(benzamidine) components

AU - Sánchez, Mateo I.

AU - Mosquera, Jesús

AU - Vázquez, M. Eugenio

AU - Mascareñas, José L.

PY - 2014/9/8

Y1 - 2014/9/8

N2 - At specific DNA sites, nickel(II) salts promote the assembly of designed components, namely a bis(histidine)-modified peptide that is derived from a bZIP transcription factor and a bis(benzamidine) unit that is equipped with a bipyridine. This programmed supramolecular system with emergent properties reproduces some key characteristics of naturally occurring DNA-binding proteins, such as bivalence, selectivity, responsiveness to external agents, and reversibility.

AB - At specific DNA sites, nickel(II) salts promote the assembly of designed components, namely a bis(histidine)-modified peptide that is derived from a bZIP transcription factor and a bis(benzamidine) unit that is equipped with a bipyridine. This programmed supramolecular system with emergent properties reproduces some key characteristics of naturally occurring DNA-binding proteins, such as bivalence, selectivity, responsiveness to external agents, and reversibility.

KW - DNA recognition

KW - minor-groove binders

KW - peptides

KW - self-assembly

KW - supramolecular chemistry

UR - https://www.scopus.com/pages/publications/84906947670

U2 - 10.1002/anie.201405726

DO - 10.1002/anie.201405726

M3 - Article

AN - SCOPUS:84906947670

SN - 1433-7851

VL - 53

SP - 9917

EP - 9921

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 37

ER -

Reversible supramolecular assembly at specific DNA Sites: nickel-promoted bivalent DNA binding with designed peptide and bipyridyl-bis(benzamidine) components

Abstract

Keywords

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