Reversible supramolecular assembly at specific DNA Sites: nickel-promoted bivalent DNA binding with designed peptide and bipyridyl-bis(benzamidine) components

Mateo I. Sánchez, Jesús Mosquera, M. Eugenio Vázquez, José L. Mascareñas

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

At specific DNA sites, nickel(II) salts promote the assembly of designed components, namely a bis(histidine)-modified peptide that is derived from a bZIP transcription factor and a bis(benzamidine) unit that is equipped with a bipyridine. This programmed supramolecular system with emergent properties reproduces some key characteristics of naturally occurring DNA-binding proteins, such as bivalence, selectivity, responsiveness to external agents, and reversibility.

Original languageEnglish
Pages (from-to)9917-9921
Number of pages5
JournalAngewandte Chemie - International Edition
Volume53
Issue number37
DOIs
Publication statusPublished - 8 Sep 2014

Keywords

  • DNA recognition
  • minor-groove binders
  • peptides
  • self-assembly
  • supramolecular chemistry

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