Reversible electroaddressing of self-assembling amino-acid conjugates

Y. Liu, E. Kim, R. V. Ulijn, W. E. Bentley, Gregory F Payne

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The triggered assembly of organic and biological materials in response to imposed electrical signals (i.e., electroaddressing) provides interesting opportunities for applications in molecular electronics, biosensing and nano-biotechnology. Recent studies have shown that the conjugation of aromatic moieties to short peptides often yields hydrogelator compounds that can be triggered to self-assemble over a hierarchy of length scales in response to a reduction in pH. Here, we examined the capabilities of fl uorenyl-9-methoxycarbonyl- phenylalanine (Fmoc-Phe) to electrodeposit in response to an electrochemically-induced pH gradient generated at the anode surface. We report that the electrodeposition of Fmoc-Phe; is rapid (minutes), can be spatially controlled in normal and lateral directions, and can be reversed by applying a brief cathodic current. Further more, we show that Fmoc-Phe can be simultaneously deposited on one electrode address (anode) while it is being cathodically stripped from a separate electrode address of the same chip. Finally, we demonstrate that these capabilities can be extended for electroaddressing within microfl uidic channels. The reversible assembly/disassembly of molecular gelators (Fmoc-amino acids and Fmoc-peptides) in response to spatiotemporally imposed electrical signals offers unique opportunities for electroaddressing that should be especially valuable for lab-on-a-chip applications.
Original languageEnglish
Pages (from-to)1575-1580
Number of pages6
JournalAdvanced Functional Materials
Volume21
Issue number9
DOIs
Publication statusPublished - 10 May 2011

Keywords

  • microarrays
  • carbon surfaces
  • electrode surfaces
  • composite films
  • protein
  • chitosan films
  • covalent immobilization
  • supramolecular hydrogels
  • selective immobilization
  • electrochemical oxidation
  • reversible
  • electroaddressing
  • self-assembling
  • amino-acid conjugates

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