Reversible DNA micro-patterning using the fluorous effect

Gabriella Flynn, Jamie Withers, Gerard Macias, Justin R. Sperlin, Sarah L. Henry, Jonathan M. Cooper, Glenn A. Burley, Alasdair W. Clark

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)
104 Downloads (Pure)

Abstract

We describe a new method for the immobilisation of DNA into defined patterns with sub-micron resolution, using the fluorous effect. The method is fully reversible via a simple solvent wash, allowing the patterning, regeneration and re-patterning of surfaces with no degradation in binding efficiency following multiple removal/attachment cycles of different DNA sequences.
Original languageEnglish
Pages (from-to)3094-3097
Number of pages4
JournalChemical Communications
Volume53
Issue number21
DOIs
Publication statusPublished - 23 Feb 2017

Keywords

  • DNA immobilisation
  • sub-micron resolution
  • fluorous effect
  • molecular surface patterning
  • oligodeoxyribonucleotides
  • nonspecific binding

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