Reversed cortical over-activity during movement imagination following neurofeedback treatment for central neuropathic pain

Muhammad Abul Hasan, Matthew Fraser, Bernard A Conway, David B. Allan, Aleksandra Vučković

Research output: Contribution to journalArticle

4 Citations (Scopus)
45 Downloads (Pure)

Abstract

OBJECTIVE: One of the brain signatures of the central neuropathic pain (CNP) is the theta band over-activity of wider cortical structures, during imagination of movement. The objective of the study was to investigate whether this over-activity is reversible following the neurofeedback treatment of CNP.

METHODS: Five paraplegic patients with pain in their legs underwent from twenty to forty neurofeedback sessions that significantly reduced their pain. In order to assess their dynamic cortical activity they were asked to imagine movements of all limbs a week before the first and a week after the last neurofeedback session. Using time-frequency analysis we compared EEG activity during imagination of movement before and after the therapy and further compared it with EEG signals of ten paraplegic patients with no pain and a control group of ten able-bodied people.

RESULTS: Neurofeedback treatment resulted in reduced CNP and a wide spread reduction of cortical activity during imagination of movement. The reduction was significant in the alpha and beta band but was largest in the theta band. As a result cortical activity became similar to the activity of other two groups with no pain.

CONCLUSIONS: Reduction of CNP is accompanied by reduced cortical over-activity during movement imagination.

SIGNIFICANCE: Understanding causes and consequences mechanism through which CNP affects cortical activity.

Original languageEnglish
Pages (from-to)3118-27
Number of pages10
JournalClinical Neurophysiology
Volume127
Issue number9
Early online date24 Jun 2016
DOIs
Publication statusPublished - 30 Sep 2016

Fingerprint

Neurofeedback
Imagination
Neuralgia
Pain
Electroencephalography
Therapeutics
Leg
Extremities
Control Groups
Brain

Keywords

  • central neuropathic pain
  • neurofeedback
  • eeg
  • motor imagery
  • theta band
  • dynamic cortical activity
  • paraplegic patients

Cite this

Hasan, Muhammad Abul ; Fraser, Matthew ; Conway, Bernard A ; Allan, David B. ; Vučković, Aleksandra. / Reversed cortical over-activity during movement imagination following neurofeedback treatment for central neuropathic pain. In: Clinical Neurophysiology. 2016 ; Vol. 127, No. 9. pp. 3118-27.
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Reversed cortical over-activity during movement imagination following neurofeedback treatment for central neuropathic pain. / Hasan, Muhammad Abul; Fraser, Matthew; Conway, Bernard A; Allan, David B.; Vučković, Aleksandra.

In: Clinical Neurophysiology, Vol. 127, No. 9, 30.09.2016, p. 3118-27.

Research output: Contribution to journalArticle

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AU - Fraser, Matthew

AU - Conway, Bernard A

AU - Allan, David B.

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N1 - Copyright © 2016 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

PY - 2016/9/30

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N2 - OBJECTIVE: One of the brain signatures of the central neuropathic pain (CNP) is the theta band over-activity of wider cortical structures, during imagination of movement. The objective of the study was to investigate whether this over-activity is reversible following the neurofeedback treatment of CNP.METHODS: Five paraplegic patients with pain in their legs underwent from twenty to forty neurofeedback sessions that significantly reduced their pain. In order to assess their dynamic cortical activity they were asked to imagine movements of all limbs a week before the first and a week after the last neurofeedback session. Using time-frequency analysis we compared EEG activity during imagination of movement before and after the therapy and further compared it with EEG signals of ten paraplegic patients with no pain and a control group of ten able-bodied people.RESULTS: Neurofeedback treatment resulted in reduced CNP and a wide spread reduction of cortical activity during imagination of movement. The reduction was significant in the alpha and beta band but was largest in the theta band. As a result cortical activity became similar to the activity of other two groups with no pain.CONCLUSIONS: Reduction of CNP is accompanied by reduced cortical over-activity during movement imagination.SIGNIFICANCE: Understanding causes and consequences mechanism through which CNP affects cortical activity.

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