Abstract
| Language | English |
|---|---|
| Pages | 352-358 |
| Number of pages | 6 |
| Journal | Sensors and Actuators B: Chemical |
| Volume | 129 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2008 |
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Keywords
- reverse iontophoresis
- iontophoresis
- lactate
- monitoring
- non-invasive
- bioengineering
Cite this
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Reverse iontophoresis: a non-invasive technique for measuring blood lactate level. / Ching, C.T.S.; Connolly, P.
In: Sensors and Actuators B: Chemical, Vol. 129, No. 1, 01.2008, p. 352-358.Research output: Contribution to journal › Article
TY - JOUR
T1 - Reverse iontophoresis: a non-invasive technique for measuring blood lactate level
AU - Ching, C.T.S.
AU - Connolly, P.
PY - 2008/1
Y1 - 2008/1
N2 - Blood lactate monitoring is beneficial to many patients, e.g. critical care patients. However, there are very few non-invasive or continuous monitoring systems for this parameter and significant clinical benefit could be achieved if such systems were readily available. Therefore, the aim of the current study was to investigate the possibility of non-invasively extracting lactate from blood through skin using reverse iontophoresis to monitor blood lactate levels in humans. In vitro reverse iontophoresis studies have indicated that the optimum switching mode for reverse iontophoresis of lactate is continuous direct current but application of current combined with electrode polarity reversal every 15 min was suggested to be used in humans. The reverse iontophoresis technique was applied to 10 healthy volunteers and lactate was successfully extracted through their skin into the methylcellulose gel of the electrodes. A moderate correlation (r2 = 0.6) between lactate concentrations in collection gels and lactate levels in the blood was observed after an outlier was removed from the regression equation. The result suggests that it may be possible to non-invasively monitor the blood lactate levels using reverse iontophoresis technique.
AB - Blood lactate monitoring is beneficial to many patients, e.g. critical care patients. However, there are very few non-invasive or continuous monitoring systems for this parameter and significant clinical benefit could be achieved if such systems were readily available. Therefore, the aim of the current study was to investigate the possibility of non-invasively extracting lactate from blood through skin using reverse iontophoresis to monitor blood lactate levels in humans. In vitro reverse iontophoresis studies have indicated that the optimum switching mode for reverse iontophoresis of lactate is continuous direct current but application of current combined with electrode polarity reversal every 15 min was suggested to be used in humans. The reverse iontophoresis technique was applied to 10 healthy volunteers and lactate was successfully extracted through their skin into the methylcellulose gel of the electrodes. A moderate correlation (r2 = 0.6) between lactate concentrations in collection gels and lactate levels in the blood was observed after an outlier was removed from the regression equation. The result suggests that it may be possible to non-invasively monitor the blood lactate levels using reverse iontophoresis technique.
KW - reverse iontophoresis
KW - iontophoresis
KW - lactate
KW - monitoring
KW - non-invasive
KW - bioengineering
UR - http://dx.doi.org/10.1016/j.snb.2007.08.031
U2 - 10.1016/j.snb.2007.08.031
DO - 10.1016/j.snb.2007.08.031
M3 - Article
VL - 129
SP - 352
EP - 358
JO - Sensors and Actuators B: Chemical
T2 - Sensors and Actuators B: Chemical
JF - Sensors and Actuators B: Chemical
SN - 0925-4005
IS - 1
ER -