Reverse iontophoresis: a non-invasive technique for measuring blood lactate level

C.T.S. Ching, P. Connolly

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    Blood lactate monitoring is beneficial to many patients, e.g. critical care patients. However, there are very few non-invasive or continuous monitoring systems for this parameter and significant clinical benefit could be achieved if such systems were readily available. Therefore, the aim of the current study was to investigate the possibility of non-invasively extracting lactate from blood through skin using reverse iontophoresis to monitor blood lactate levels in humans. In vitro reverse iontophoresis studies have indicated that the optimum switching mode for reverse iontophoresis of lactate is continuous direct current but application of current combined with electrode polarity reversal every 15 min was suggested to be used in humans. The reverse iontophoresis technique was applied to 10 healthy volunteers and lactate was successfully extracted through their skin into the methylcellulose gel of the electrodes. A moderate correlation (r2 = 0.6) between lactate concentrations in collection gels and lactate levels in the blood was observed after an outlier was removed from the regression equation. The result suggests that it may be possible to non-invasively monitor the blood lactate levels using reverse iontophoresis technique.
    LanguageEnglish
    Pages352-358
    Number of pages6
    JournalSensors and Actuators B: Chemical
    Volume129
    Issue number1
    DOIs
    Publication statusPublished - Jan 2008

    Fingerprint

    lactates
    blood
    Lactic Acid
    Blood
    Skin
    Gels
    Electrodes
    Monitoring
    gels
    Methylcellulose
    electrodes
    Iontophoresis
    regression analysis
    polarity
    direct current

    Keywords

    • reverse iontophoresis
    • iontophoresis
    • lactate
    • monitoring
    • non-invasive
    • bioengineering

    Cite this

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    title = "Reverse iontophoresis: a non-invasive technique for measuring blood lactate level",
    abstract = "Blood lactate monitoring is beneficial to many patients, e.g. critical care patients. However, there are very few non-invasive or continuous monitoring systems for this parameter and significant clinical benefit could be achieved if such systems were readily available. Therefore, the aim of the current study was to investigate the possibility of non-invasively extracting lactate from blood through skin using reverse iontophoresis to monitor blood lactate levels in humans. In vitro reverse iontophoresis studies have indicated that the optimum switching mode for reverse iontophoresis of lactate is continuous direct current but application of current combined with electrode polarity reversal every 15 min was suggested to be used in humans. The reverse iontophoresis technique was applied to 10 healthy volunteers and lactate was successfully extracted through their skin into the methylcellulose gel of the electrodes. A moderate correlation (r2 = 0.6) between lactate concentrations in collection gels and lactate levels in the blood was observed after an outlier was removed from the regression equation. The result suggests that it may be possible to non-invasively monitor the blood lactate levels using reverse iontophoresis technique.",
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    Reverse iontophoresis: a non-invasive technique for measuring blood lactate level. / Ching, C.T.S.; Connolly, P.

    In: Sensors and Actuators B: Chemical, Vol. 129, No. 1, 01.2008, p. 352-358.

    Research output: Contribution to journalArticle

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    AU - Connolly, P.

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    N2 - Blood lactate monitoring is beneficial to many patients, e.g. critical care patients. However, there are very few non-invasive or continuous monitoring systems for this parameter and significant clinical benefit could be achieved if such systems were readily available. Therefore, the aim of the current study was to investigate the possibility of non-invasively extracting lactate from blood through skin using reverse iontophoresis to monitor blood lactate levels in humans. In vitro reverse iontophoresis studies have indicated that the optimum switching mode for reverse iontophoresis of lactate is continuous direct current but application of current combined with electrode polarity reversal every 15 min was suggested to be used in humans. The reverse iontophoresis technique was applied to 10 healthy volunteers and lactate was successfully extracted through their skin into the methylcellulose gel of the electrodes. A moderate correlation (r2 = 0.6) between lactate concentrations in collection gels and lactate levels in the blood was observed after an outlier was removed from the regression equation. The result suggests that it may be possible to non-invasively monitor the blood lactate levels using reverse iontophoresis technique.

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